FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2991543550> ?p ?o ?g. }

• W2991543550 endingPage "745" @default.
• W2991543550 startingPage "723" @default.
• W2991543550 abstract "Bleomycin (BLM) is a chemotherapeutic agent which is associated with Idiopathic pulmonary fibrosis (IPF) due to its chronic administration. Hesperidin, a bioflavonoid has been reported to possess antioxidant, anti-inflammatory, wound healing, and antiapoptotic potential. To evaluate the therapeutic potential of hesperidin against BLM-induced pulmonary fibrosis and decipher its possible mechanism of action. Intraperitoneal administration of BLM (6 IU/kg) caused induction of IPF in Sprague-Dawley rats. Rats were treated with hesperidin (25, 50, and 100 mg/kg, p.o.) for 28 days, followed by estimation of various parameters in bronchoalveolar lavage fluid (BALF) and lung. Hesperidin (50 and 100 mg/kg) administration significantly ameliorated (p < 0.05) alterations induced by BLM in lung index, percent oxygen saturation, serum ALP and LDH levels, BALF differential cell count, and lung function test. Elevated levels of oxido-nitrosative stress, hydroxyproline, and myeloperoxidase levels in BALF and lung were significantly decreased by hesperidin on day 14. Hesperidin significantly inhibited BLM-induced down-regulated lung Nrf2 and HO-1 as well as up-regulated TNF-α, IL-1β, IL-6, collagen-1, TGF-β, and Smad-3 mRNA expressions. Western blot analysis showed that alteration in lung NF-κB, IκBα, AMPK, and PP2C-α protein expressions were ameliorated by hesperidin on day 28. Furthermore, BLM induced histological and ultrastructural aberrations in the lung which were attenuated by hesperidin treatment. Hesperidin alleviates BLM-induced IPF via inhibition of TGF-β1/Smad3/AMPK and IκBα/NF-κB pathways which in turn ameliorate the modulation of oxido-inflammatory markers (Nrf2 and HO-1) and pro-inflammatory markers (TNF-α, IL-1β, and IL-6) to reduce collagen deposition during pulmonary fibrosis. See also Figure 1(Fig. 1)." @default.
• W2991543550 created "2019-12-05" @default.
• W2991543550 creator A5000496283 @default.
• W2991543550 creator A5017803794 @default.
• W2991543550 creator A5032131709 @default.
• W2991543550 creator A5055096746 @default.
• W2991543550 date "2019-01-01" @default.
• W2991543550 modified "2023-09-23" @default.
• W2991543550 title "Hesperidin ameliorates bleomycin-induced experimental pulmonary fibrosis via inhibition of TGF-beta1/Smad3/AMPK and IkappaBalpha/NF-kappaB pathways." @default.
• W2991543550 cites W1598988227 @default.
• W2991543550 cites W1938547050 @default.
• W2991543550 cites W1965085659 @default.
• W2991543550 cites W1965726670 @default.
• W2991543550 cites W1980164182 @default.
• W2991543550 cites W1984468751 @default.
• W2991543550 cites W1985589051 @default.
• W2991543550 cites W1989338939 @default.
• W2991543550 cites W2004522765 @default.
• W2991543550 cites W2012168857 @default.
• W2991543550 cites W2026501434 @default.
• W2991543550 cites W2031034395 @default.
• W2991543550 cites W2036940115 @default.
• W2991543550 cites W2042121916 @default.
• W2991543550 cites W2043638349 @default.
• W2991543550 cites W2045487707 @default.
• W2991543550 cites W2046039539 @default.
• W2991543550 cites W2053833403 @default.
• W2991543550 cites W2058339334 @default.
• W2991543550 cites W2066691510 @default.
• W2991543550 cites W2073353515 @default.
• W2991543550 cites W2080327048 @default.
• W2991543550 cites W2083312306 @default.
• W2991543550 cites W2090647413 @default.
• W2991543550 cites W2100480463 @default.
• W2991543550 cites W2100880370 @default.
• W2991543550 cites W2111791469 @default.
• W2991543550 cites W2114054457 @default.
• W2991543550 cites W2114066730 @default.
• W2991543550 cites W2121621792 @default.
• W2991543550 cites W2123137799 @default.
• W2991543550 cites W2132133452 @default.
• W2991543550 cites W2132658958 @default.
• W2991543550 cites W2169699497 @default.
• W2991543550 cites W2170331002 @default.
• W2991543550 cites W2170877190 @default.
• W2991543550 cites W2219065003 @default.
• W2991543550 cites W2330806633 @default.
• W2991543550 cites W2392929672 @default.
• W2991543550 cites W2470630812 @default.
• W2991543550 cites W2545670167 @default.
• W2991543550 cites W2565620662 @default.
• W2991543550 cites W2580873891 @default.
• W2991543550 cites W2600110309 @default.
• W2991543550 cites W2737785069 @default.
• W2991543550 cites W2737832093 @default.
• W2991543550 cites W2739715566 @default.
• W2991543550 cites W2746040851 @default.
• W2991543550 cites W2747104363 @default.
• W2991543550 cites W2754296049 @default.
• W2991543550 cites W2773154348 @default.
• W2991543550 cites W2789727516 @default.
• W2991543550 cites W2795524640 @default.
• W2991543550 cites W2807833206 @default.
• W2991543550 cites W2809779343 @default.
• W2991543550 cites W2891000139 @default.
• W2991543550 cites W2895854040 @default.
• W2991543550 cites W2901411145 @default.
• W2991543550 cites W2907542787 @default.
• W2991543550 cites W2945655565 @default.
• W2991543550 cites W296319558 @default.
• W2991543550 doi "https://doi.org/10.17179/excli2019-1094" @default.
• W2991543550 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6785776" @default.
• W2991543550 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31611754" @default.
• W2991543550 hasPublicationYear "2019" @default.
• W2991543550 type Work @default.
• W2991543550 sameAs 2991543550 @default.
• W2991543550 citedByCount "19" @default.
• W2991543550 countsByYear W29915435502020 @default.
• W2991543550 countsByYear W29915435502021 @default.
• W2991543550 countsByYear W29915435502022 @default.
• W2991543550 countsByYear W29915435502023 @default.
• W2991543550 crossrefType "journal-article" @default.
• W2991543550 hasAuthorship W2991543550A5000496283 @default.
• W2991543550 hasAuthorship W2991543550A5017803794 @default.
• W2991543550 hasAuthorship W2991543550A5032131709 @default.
• W2991543550 hasAuthorship W2991543550A5055096746 @default.
• W2991543550 hasConcept C104317684 @default.
• W2991543550 hasConcept C126322002 @default.
• W2991543550 hasConcept C142724271 @default.
• W2991543550 hasConcept C185592680 @default.
• W2991543550 hasConcept C204787440 @default.
• W2991543550 hasConcept C2776128092 @default.
• W2991543550 hasConcept C2776232574 @default.
• W2991543550 hasConcept C2776415932 @default.
• W2991543550 hasConcept C2776694085 @default.
• W2991543550 hasConcept C2777714996 @default.
• W2991543550 hasConcept C2778341716 @default.
• W2991543550 hasConcept C2779797417 @default.

• next