FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2991546632> ?p ?o ?g. }

• W2991546632 endingPage "982" @default.
• W2991546632 startingPage "975" @default.
• W2991546632 abstract "Background Management of avulsion injuries remains a challenge due to necrosis. The aim of the present study is to create an experimental model reproducing an avulsion injury and investigate the effects of hyperoxygenated solution (HOS), a method of oxygen delivery that has been widely used in the therapy of ischaemia-hypoxia diseases, on avulsion injury flap survival in rats. Methods Forty male rats were divided into four groups (n = 10 each). Dorsal random pattern flaps measuring 3 × 9 cm, including the panniculus carnosus, were elevated and run over by the skin avulsion model machine, and the flaps were then sutured into their original places. The sham+HOS and avulsion+HOS groups received intravenous HOS (20 ml/kg) each day for 7 days after the operation. The sham+saline and avulsion+saline groups received intravenous saline solution (20 ml/kg) each day for 7 days after the operation. Percutaneous O2 pressure (TcpO2) measurement, serial examinations of skin flap blood perfusion, skin flap survival evaluation and histopathology were performed to assess the efficacy of HOS on avulsion injury. Results Compared to the avulsion+saline groups, TcpO2 was significantly higher in the avulsion+HOS groups at 15, 30 and 60 min after infusion (P < 0.05). The blood perfusion of flaps in the avulsion+HOS group was higher than in the avulsion+saline group (P < 0.05). The survival rate was higher in the avulsion+HOS group than in the avulsion+saline group (P < 0.05), and the histopathology assays supported the data. Conclusion We succeeded in developing an avulsion injury model and demonstrated that HOS could improve the survival of the avulsion injury flaps in rats by effectively increasing the local oxygen content and blood perfusion and ameliorating inflammatory damage. Management of avulsion injuries remains a challenge due to necrosis. The aim of the present study is to create an experimental model reproducing an avulsion injury and investigate the effects of hyperoxygenated solution (HOS), a method of oxygen delivery that has been widely used in the therapy of ischaemia-hypoxia diseases, on avulsion injury flap survival in rats. Forty male rats were divided into four groups (n = 10 each). Dorsal random pattern flaps measuring 3 × 9 cm, including the panniculus carnosus, were elevated and run over by the skin avulsion model machine, and the flaps were then sutured into their original places. The sham+HOS and avulsion+HOS groups received intravenous HOS (20 ml/kg) each day for 7 days after the operation. The sham+saline and avulsion+saline groups received intravenous saline solution (20 ml/kg) each day for 7 days after the operation. Percutaneous O2 pressure (TcpO2) measurement, serial examinations of skin flap blood perfusion, skin flap survival evaluation and histopathology were performed to assess the efficacy of HOS on avulsion injury. Compared to the avulsion+saline groups, TcpO2 was significantly higher in the avulsion+HOS groups at 15, 30 and 60 min after infusion (P < 0.05). The blood perfusion of flaps in the avulsion+HOS group was higher than in the avulsion+saline group (P < 0.05). The survival rate was higher in the avulsion+HOS group than in the avulsion+saline group (P < 0.05), and the histopathology assays supported the data. We succeeded in developing an avulsion injury model and demonstrated that HOS could improve the survival of the avulsion injury flaps in rats by effectively increasing the local oxygen content and blood perfusion and ameliorating inflammatory damage." @default.
• W2991546632 created "2019-12-05" @default.
• W2991546632 creator A5033761660 @default.
• W2991546632 creator A5045703368 @default.
• W2991546632 creator A5068851817 @default.
• W2991546632 creator A5086170656 @default.
• W2991546632 creator A5090702709 @default.
• W2991546632 date "2020-05-01" @default.
• W2991546632 modified "2023-10-12" @default.
• W2991546632 title "Hyperoxygenated solution improves tissue viability in an avulsion injury flap model" @default.
• W2991546632 cites W1507691543 @default.
• W2991546632 cites W1983082416 @default.
• W2991546632 cites W2018964211 @default.
• W2991546632 cites W2054266191 @default.
• W2991546632 cites W2060116586 @default.
• W2991546632 cites W2062366949 @default.
• W2991546632 cites W2068618189 @default.
• W2991546632 cites W2068626369 @default.
• W2991546632 cites W2068975040 @default.
• W2991546632 cites W2069155039 @default.
• W2991546632 cites W2069272821 @default.
• W2991546632 cites W2076473067 @default.
• W2991546632 cites W2081185687 @default.
• W2991546632 cites W2094718054 @default.
• W2991546632 cites W2103445843 @default.
• W2991546632 cites W2106283439 @default.
• W2991546632 cites W2137701566 @default.
• W2991546632 cites W2146108270 @default.
• W2991546632 cites W2169039965 @default.
• W2991546632 cites W2170492610 @default.
• W2991546632 cites W2312828454 @default.
• W2991546632 cites W2319509380 @default.
• W2991546632 cites W2332493865 @default.
• W2991546632 cites W2609175283 @default.
• W2991546632 doi "https://doi.org/10.1016/j.bjps.2019.11.029" @default.
• W2991546632 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31899115" @default.
• W2991546632 hasPublicationYear "2020" @default.
• W2991546632 type Work @default.
• W2991546632 sameAs 2991546632 @default.
• W2991546632 citedByCount "3" @default.
• W2991546632 countsByYear W29915466322020 @default.
• W2991546632 countsByYear W29915466322022 @default.
• W2991546632 countsByYear W29915466322023 @default.
• W2991546632 crossrefType "journal-article" @default.
• W2991546632 hasAuthorship W2991546632A5033761660 @default.
• W2991546632 hasAuthorship W2991546632A5045703368 @default.
• W2991546632 hasAuthorship W2991546632A5068851817 @default.
• W2991546632 hasAuthorship W2991546632A5086170656 @default.
• W2991546632 hasAuthorship W2991546632A5090702709 @default.
• W2991546632 hasConcept C126322002 @default.
• W2991546632 hasConcept C141071460 @default.
• W2991546632 hasConcept C146957229 @default.
• W2991546632 hasConcept C2777196621 @default.
• W2991546632 hasConcept C2777397205 @default.
• W2991546632 hasConcept C37754001 @default.
• W2991546632 hasConcept C42219234 @default.
• W2991546632 hasConcept C71924100 @default.
• W2991546632 hasConceptScore W2991546632C126322002 @default.
• W2991546632 hasConceptScore W2991546632C141071460 @default.
• W2991546632 hasConceptScore W2991546632C146957229 @default.
• W2991546632 hasConceptScore W2991546632C2777196621 @default.
• W2991546632 hasConceptScore W2991546632C2777397205 @default.
• W2991546632 hasConceptScore W2991546632C37754001 @default.
• W2991546632 hasConceptScore W2991546632C42219234 @default.
• W2991546632 hasConceptScore W2991546632C71924100 @default.
• W2991546632 hasFunder F4320336035 @default.
• W2991546632 hasIssue "5" @default.
• W2991546632 hasLocation W29915466321 @default.
• W2991546632 hasLocation W29915466322 @default.
• W2991546632 hasOpenAccess W2991546632 @default.
• W2991546632 hasPrimaryLocation W29915466321 @default.
• W2991546632 hasRelatedWork W2054757176 @default.
• W2991546632 hasRelatedWork W2087394050 @default.
• W2991546632 hasRelatedWork W2145322444 @default.
• W2991546632 hasRelatedWork W2205984738 @default.
• W2991546632 hasRelatedWork W2365999184 @default.
• W2991546632 hasRelatedWork W2366554047 @default.
• W2991546632 hasRelatedWork W2372943482 @default.
• W2991546632 hasRelatedWork W2380714454 @default.
• W2991546632 hasRelatedWork W2415978481 @default.
• W2991546632 hasRelatedWork W2991546632 @default.
• W2991546632 hasVolume "73" @default.
• W2991546632 isParatext "false" @default.
• W2991546632 isRetracted "false" @default.
• W2991546632 magId "2991546632" @default.
• W2991546632 workType "article" @default.