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- W2991551504 abstract "Few studies have considered the impact of lead exposures at multiple developmental stages on pubertal onset or relationships with hormones influencing secondary sexual characteristics. We examined prenatal, early childhood and concurrent lead exposure in relation to pubertal onset and fasting serum hormone concentrations at ages 8-14 in a Mexican birth cohort. We estimated associations of maternal bone lead at 1-month postpartum and blood lead levels (umbilical cord, cumulative 1-4 yr of age, concurrent) with odds of physician-assessed Tanner stage >=2 in boys (N=117; genitalia (G) and pubic hair (P)) and in girls (N=131; breast (B), pubic hair, menarche) and with log-transformed concentrations of dehydroepiandrosterone sulfate (DHEA-S), estradiol (E2), inhibin B, sex-hormone binding globulin (SHBG), and testosterone (T) with multivariable logistic and linear regression, respectively, adjusting for age, BMI-Z score and maternal education.Lead levels were: patella, 8.9±10.2 µg/g bone; tibia, 7.4±9.7 µg/g; loge-umbilical cord blood, 3.7±2.1 µg/dL; 1-4 year loge-blood (cumulative), 14.4±1.4 µg/dL; loge-current blood, 3.3±2.8 µg/dL. In girls, a loge-µg/dL increase in current blood lead was associated with 0.42 lower odds (95%CI: 0.21-0.83) of >=P2, and patella lead was negatively associated with inhibin B (β=-0.014, p=0.02). In boys, cord blood and tibia lead were positively associated with DHEA-S (β=0.323 p=0.004; β=0.021, p=0.002, respectively), a loge- dL increase in cumulative blood lead from 1-4 yr was associated with a -1.141 decrease in T (p=0.007), and patella lead was positively associated with SHBG (β= 0.011, p=0.01). Findings suggest early life lead exposures may be negatively associated with pubertal onset in girls and blood levels of specific sex hormones in boys and girls. Prenatal lead exposure was positively associated with hormones influencing adrenarche in boys while concurrent exposure may be related to delayed pubarche in girls." @default.
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- W2991551504 date "2014-10-20" @default.
- W2991551504 modified "2023-10-16" @default.
- W2991551504 title "Association of Life Stage Lead Exposures with Pubertal Onset and Hormones Related to Secondary Sexual Characteristics in a Mexican Birth Cohort" @default.
- W2991551504 doi "https://doi.org/10.1289/isee.2014.o-232" @default.
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