Matches in SemOpenAlex for { <https://semopenalex.org/work/W2991562105> ?p ?o ?g. }
- W2991562105 abstract "Abstract Human postmortem studies suggest a major role for abnormalities in GABAergic interneurons in the prefrontal cortex in schizophrenia. Cortical interneurons differentiated from induced pluripotent stem cells (iPSCs) of schizophrenia subjects showed significantly lower levels of glutamate decarboxylase 67 (GAD67), replicating findings from multiple postmortem studies, as well as reduced levels of synaptic proteins gehpyrin and NLGN2. Co-cultures of the interneurons with excitatory cortical pyramidal neurons from schizophrenia iPSCs showed reduced synaptic puncta density and lower action potential frequency. NLGN2 overexpression in schizophrenia neurons rescued synaptic puncta deficits while NLGN2 knockdown in healthy neurons resulted in reduced synaptic puncta density. Schizophrenia interneurons also had significantly smaller nuclear area, suggesting an innate oxidative stressed state. The antioxidant N -acetylcysteine increased the nuclear area in schizophrenia interneurons, increased NLGN2 expression and rescued synaptic deficits. These results implicate specific deficiencies in the synaptic machinery in cortical interneurons as critical regulators of synaptic connections in schizophrenia and point to a nexus between oxidative stress and NLGN2 expression in mediating synaptic deficits in schizophrenia." @default.
- W2991562105 created "2019-12-05" @default.
- W2991562105 creator A5003601430 @default.
- W2991562105 creator A5012233991 @default.
- W2991562105 creator A5032951437 @default.
- W2991562105 creator A5055232030 @default.
- W2991562105 creator A5087258143 @default.
- W2991562105 creator A5091796070 @default.
- W2991562105 date "2019-11-28" @default.
- W2991562105 modified "2023-10-12" @default.
- W2991562105 title "Synaptic deficits in iPSC-derived cortical interneurons in schizophrenia are mediated by NLGN2 and rescued by N-acetylcysteine" @default.
- W2991562105 cites W1127059495 @default.
- W2991562105 cites W1924622891 @default.
- W2991562105 cites W1963724713 @default.
- W2991562105 cites W1968700646 @default.
- W2991562105 cites W2017887802 @default.
- W2991562105 cites W2024425201 @default.
- W2991562105 cites W2034651412 @default.
- W2991562105 cites W2040188303 @default.
- W2991562105 cites W2040727823 @default.
- W2991562105 cites W2070106501 @default.
- W2991562105 cites W2082314612 @default.
- W2991562105 cites W2092270879 @default.
- W2991562105 cites W2103592460 @default.
- W2991562105 cites W2105730072 @default.
- W2991562105 cites W2116341319 @default.
- W2991562105 cites W2124433160 @default.
- W2991562105 cites W2140668459 @default.
- W2991562105 cites W2141263950 @default.
- W2991562105 cites W2149288810 @default.
- W2991562105 cites W2152492589 @default.
- W2991562105 cites W2156026059 @default.
- W2991562105 cites W2156890482 @default.
- W2991562105 cites W2159400463 @default.
- W2991562105 cites W2161378898 @default.
- W2991562105 cites W2162916231 @default.
- W2991562105 cites W2166279367 @default.
- W2991562105 cites W2166739899 @default.
- W2991562105 cites W2170696995 @default.
- W2991562105 cites W2173821398 @default.
- W2991562105 cites W2188981783 @default.
- W2991562105 cites W2200686875 @default.
- W2991562105 cites W2239633304 @default.
- W2991562105 cites W2308256741 @default.
- W2991562105 cites W2334244908 @default.
- W2991562105 cites W2523393682 @default.
- W2991562105 cites W2547648658 @default.
- W2991562105 cites W2548843663 @default.
- W2991562105 cites W2598412808 @default.
- W2991562105 cites W2602914130 @default.
- W2991562105 cites W2737227438 @default.
- W2991562105 cites W2783726586 @default.
- W2991562105 cites W2795334944 @default.
- W2991562105 cites W2801290777 @default.
- W2991562105 cites W2892460697 @default.
- W2991562105 cites W2896279357 @default.
- W2991562105 cites W2896631355 @default.
- W2991562105 cites W2904402580 @default.
- W2991562105 cites W2911701742 @default.
- W2991562105 cites W2922075722 @default.
- W2991562105 cites W2942055511 @default.
- W2991562105 cites W2950144312 @default.
- W2991562105 cites W2960513269 @default.
- W2991562105 cites W2964363722 @default.
- W2991562105 cites W4211032287 @default.
- W2991562105 doi "https://doi.org/10.1038/s41398-019-0660-x" @default.
- W2991562105 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6882825" @default.
- W2991562105 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31780643" @default.
- W2991562105 hasPublicationYear "2019" @default.
- W2991562105 type Work @default.
- W2991562105 sameAs 2991562105 @default.
- W2991562105 citedByCount "43" @default.
- W2991562105 countsByYear W29915621052020 @default.
- W2991562105 countsByYear W29915621052021 @default.
- W2991562105 countsByYear W29915621052022 @default.
- W2991562105 countsByYear W29915621052023 @default.
- W2991562105 crossrefType "journal-article" @default.
- W2991562105 hasAuthorship W2991562105A5003601430 @default.
- W2991562105 hasAuthorship W2991562105A5012233991 @default.
- W2991562105 hasAuthorship W2991562105A5032951437 @default.
- W2991562105 hasAuthorship W2991562105A5055232030 @default.
- W2991562105 hasAuthorship W2991562105A5087258143 @default.
- W2991562105 hasAuthorship W2991562105A5091796070 @default.
- W2991562105 hasBestOaLocation W29915621051 @default.
- W2991562105 hasConcept C112592302 @default.
- W2991562105 hasConcept C118552586 @default.
- W2991562105 hasConcept C15744967 @default.
- W2991562105 hasConcept C169760540 @default.
- W2991562105 hasConcept C169900460 @default.
- W2991562105 hasConcept C170493617 @default.
- W2991562105 hasConcept C17077164 @default.
- W2991562105 hasConcept C181199279 @default.
- W2991562105 hasConcept C2776412080 @default.
- W2991562105 hasConcept C2779177108 @default.
- W2991562105 hasConcept C2779296341 @default.
- W2991562105 hasConcept C2781195155 @default.
- W2991562105 hasConcept C55493867 @default.
- W2991562105 hasConcept C61174792 @default.
- W2991562105 hasConcept C86803240 @default.
- W2991562105 hasConcept C9497952 @default.