Matches in SemOpenAlex for { <https://semopenalex.org/work/W2991572522> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2991572522 abstract "Although molecular self-organization and pattern formation are key features of life, only very few pattern-forming biochemical systems have been identified that can be reconstituted and studied in vitro under defined conditions. A systematic understanding of the underlying mechanisms is often hampered by multiple interactions, conformational flexibility and other complex features of the pattern forming proteins. Because of its compositional simplicity of only two proteins and a membrane, the MinDE system from Escherichia coli has in the past years been invaluable for deciphering the mechanisms of spatiotemporal self-organization in cells. Here, we explored the potential of reducing the complexity of this system even further, by identifying key functional motifs in the effector MinE that could be used to design pattern formation from scratch. In a combined approach of experiment and quantitative modeling, we show that starting from a minimal MinE-MinD interaction motif, pattern formation can be obtained by adding either dimerization or membrane-binding motifs. Moreover, we show that the pathways underlying pattern formation are recruitment-driven cytosolic cycling of MinE and recombination of membrane-bound MinE, and that these differ in their in vivo phenomenology." @default.
- W2991572522 created "2019-12-05" @default.
- W2991572522 creator A5008789930 @default.
- W2991572522 creator A5018596412 @default.
- W2991572522 creator A5044261222 @default.
- W2991572522 creator A5067299116 @default.
- W2991572522 creator A5086296055 @default.
- W2991572522 date "2019-11-26" @default.
- W2991572522 modified "2023-10-16" @default.
- W2991572522 title "Design of biochemical pattern forming systems from minimal motifs" @default.
- W2991572522 cites W1846301815 @default.
- W2991572522 cites W1969357685 @default.
- W2991572522 cites W1970904457 @default.
- W2991572522 cites W2008433064 @default.
- W2991572522 cites W2012235332 @default.
- W2991572522 cites W2020294018 @default.
- W2991572522 cites W2049210214 @default.
- W2991572522 cites W2057251045 @default.
- W2991572522 cites W2064225406 @default.
- W2991572522 cites W2077176951 @default.
- W2991572522 cites W2081395979 @default.
- W2991572522 cites W2090312476 @default.
- W2991572522 cites W2127811731 @default.
- W2991572522 cites W2131252553 @default.
- W2991572522 cites W2153979160 @default.
- W2991572522 cites W2164464592 @default.
- W2991572522 cites W2238978610 @default.
- W2991572522 cites W2287972295 @default.
- W2991572522 cites W2418012704 @default.
- W2991572522 cites W2553495781 @default.
- W2991572522 cites W2624938803 @default.
- W2991572522 cites W2779774681 @default.
- W2991572522 cites W2793863782 @default.
- W2991572522 cites W2801140473 @default.
- W2991572522 cites W2884493069 @default.
- W2991572522 cites W2897400705 @default.
- W2991572522 cites W2906503826 @default.
- W2991572522 cites W2962820648 @default.
- W2991572522 cites W3124033058 @default.
- W2991572522 doi "https://doi.org/10.7554/elife.48646" @default.
- W2991572522 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6922632" @default.
- W2991572522 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31767054" @default.
- W2991572522 hasPublicationYear "2019" @default.
- W2991572522 type Work @default.
- W2991572522 sameAs 2991572522 @default.
- W2991572522 citedByCount "29" @default.
- W2991572522 countsByYear W29915725222019 @default.
- W2991572522 countsByYear W29915725222020 @default.
- W2991572522 countsByYear W29915725222021 @default.
- W2991572522 countsByYear W29915725222022 @default.
- W2991572522 countsByYear W29915725222023 @default.
- W2991572522 crossrefType "journal-article" @default.
- W2991572522 hasAuthorship W2991572522A5008789930 @default.
- W2991572522 hasAuthorship W2991572522A5018596412 @default.
- W2991572522 hasAuthorship W2991572522A5044261222 @default.
- W2991572522 hasAuthorship W2991572522A5067299116 @default.
- W2991572522 hasAuthorship W2991572522A5086296055 @default.
- W2991572522 hasBestOaLocation W29915725221 @default.
- W2991572522 hasConcept C12554922 @default.
- W2991572522 hasConcept C132677234 @default.
- W2991572522 hasConcept C185592680 @default.
- W2991572522 hasConcept C51785407 @default.
- W2991572522 hasConcept C55493867 @default.
- W2991572522 hasConcept C70721500 @default.
- W2991572522 hasConcept C86803240 @default.
- W2991572522 hasConcept C95444343 @default.
- W2991572522 hasConceptScore W2991572522C12554922 @default.
- W2991572522 hasConceptScore W2991572522C132677234 @default.
- W2991572522 hasConceptScore W2991572522C185592680 @default.
- W2991572522 hasConceptScore W2991572522C51785407 @default.
- W2991572522 hasConceptScore W2991572522C55493867 @default.
- W2991572522 hasConceptScore W2991572522C70721500 @default.
- W2991572522 hasConceptScore W2991572522C86803240 @default.
- W2991572522 hasConceptScore W2991572522C95444343 @default.
- W2991572522 hasFunder F4320320879 @default.
- W2991572522 hasFunder F4320322434 @default.
- W2991572522 hasLocation W29915725221 @default.
- W2991572522 hasLocation W29915725222 @default.
- W2991572522 hasLocation W29915725223 @default.
- W2991572522 hasLocation W29915725224 @default.
- W2991572522 hasLocation W29915725225 @default.
- W2991572522 hasLocation W29915725226 @default.
- W2991572522 hasOpenAccess W2991572522 @default.
- W2991572522 hasPrimaryLocation W29915725221 @default.
- W2991572522 hasRelatedWork W1750541350 @default.
- W2991572522 hasRelatedWork W1985830493 @default.
- W2991572522 hasRelatedWork W1989312524 @default.
- W2991572522 hasRelatedWork W2014367284 @default.
- W2991572522 hasRelatedWork W2125393542 @default.
- W2991572522 hasRelatedWork W2153919606 @default.
- W2991572522 hasRelatedWork W2158352115 @default.
- W2991572522 hasRelatedWork W2255352529 @default.
- W2991572522 hasRelatedWork W4231043616 @default.
- W2991572522 hasRelatedWork W4361006988 @default.
- W2991572522 hasVolume "8" @default.
- W2991572522 isParatext "false" @default.
- W2991572522 isRetracted "false" @default.
- W2991572522 magId "2991572522" @default.
- W2991572522 workType "article" @default.