FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2991576305> ?p ?o ?g. }

• W2991576305 endingPage "e00093" @default.
• W2991576305 startingPage "e00093" @default.
• W2991576305 abstract "OBJECTIVES: Intestinal neuronal dysplasia (IND) is a common malformation of the enteric nervous system. Diagnosis requires a full-thickness colonic specimen and an experienced pathologist, emphasizing the need for noninvasive analytical methods. Recently, the methylation level of the Sox10 promoter has been found to be critical for enteric nervous system development. However, whether it can be used for diagnostic purposes in IND is unclear. METHODS: Blood and colon specimens were collected from 32 patients with IND, 60 patients with Hirschsprung disease (HD), and 60 controls. Sox10 promoter methylation in the blood and the Sox10 expression level in the colon were determined, and their correlation was analyzed. The diagnostic efficacy of blood Sox10 promoter methylation was analyzed by receiver operating characteristic curve. RESULTS: The blood level of Sox10 promoter methylation at the 32nd locus was 100% (90%–100%; 95% confidence interval [CI], 92.29%–96.37%) in control, 90% (80%–90%; 95% CI, 82.84%–87.83%) in HD, and 60% (50%–80%; 95% CI, 57.12%–69.76%) in IND specimens. Sox10 promoter methylation in the peripheral blood was negatively correlated with Sox10 expression in the colon, which was low in control, moderate in HD, and high in IND specimens (r = −0.89). The area under the curve of Sox10 promoter methylation in the diagnosis of IND was 0.94 (95% CI, 0.874–1.000, P = 0.000), with a cutoff value of 85% (sensitivity, 90.6%; specificity, 95.0%). By applying a cutoff value of 65%, promoter methylation was more indicative of IND than HD. DISCUSSION: The analysis of Sox10 promoter methylation in the peripheral blood can be used as a noninvasive method for IND diagnosis." @default.
• W2991576305 created "2019-12-05" @default.
• W2991576305 creator A5010430551 @default.
• W2991576305 creator A5024369927 @default.
• W2991576305 creator A5051024331 @default.
• W2991576305 creator A5064878038 @default.
• W2991576305 creator A5082388713 @default.
• W2991576305 creator A5083801400 @default.
• W2991576305 date "2019-12-01" @default.
• W2991576305 modified "2023-09-26" @default.
• W2991576305 title "Efficacy of Sox10 Promoter Methylation in the Diagnosis of Intestinal Neuronal Dysplasia From the Peripheral Blood" @default.
• W2991576305 cites W1927608331 @default.
• W2991576305 cites W1964155225 @default.
• W2991576305 cites W1982579705 @default.
• W2991576305 cites W1984838392 @default.
• W2991576305 cites W1990965953 @default.
• W2991576305 cites W1999605817 @default.
• W2991576305 cites W2020493895 @default.
• W2991576305 cites W2038442934 @default.
• W2991576305 cites W2038510087 @default.
• W2991576305 cites W2044163663 @default.
• W2991576305 cites W2055210467 @default.
• W2991576305 cites W2056420557 @default.
• W2991576305 cites W2062713209 @default.
• W2991576305 cites W2064388431 @default.
• W2991576305 cites W2067847863 @default.
• W2991576305 cites W2077480292 @default.
• W2991576305 cites W2086538740 @default.
• W2991576305 cites W2093170612 @default.
• W2991576305 cites W2096194550 @default.
• W2991576305 cites W2110976382 @default.
• W2991576305 cites W2123301163 @default.
• W2991576305 cites W2145753488 @default.
• W2991576305 cites W2164958561 @default.
• W2991576305 cites W2219064517 @default.
• W2991576305 cites W2296007053 @default.
• W2991576305 cites W2403600548 @default.
• W2991576305 cites W2592061403 @default.
• W2991576305 cites W2597577395 @default.
• W2991576305 cites W2605422674 @default.
• W2991576305 cites W2607438661 @default.
• W2991576305 cites W2793110535 @default.
• W2991576305 cites W2805784233 @default.
• W2991576305 cites W4296246874 @default.
• W2991576305 doi "https://doi.org/10.14309/ctg.0000000000000093" @default.
• W2991576305 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6970557" @default.
• W2991576305 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31789936" @default.
• W2991576305 hasPublicationYear "2019" @default.
• W2991576305 type Work @default.
• W2991576305 sameAs 2991576305 @default.
• W2991576305 citedByCount "3" @default.
• W2991576305 countsByYear W29915763052021 @default.
• W2991576305 countsByYear W29915763052022 @default.
• W2991576305 crossrefType "journal-article" @default.
• W2991576305 hasAuthorship W2991576305A5010430551 @default.
• W2991576305 hasAuthorship W2991576305A5024369927 @default.
• W2991576305 hasAuthorship W2991576305A5051024331 @default.
• W2991576305 hasAuthorship W2991576305A5064878038 @default.
• W2991576305 hasAuthorship W2991576305A5082388713 @default.
• W2991576305 hasAuthorship W2991576305A5083801400 @default.
• W2991576305 hasBestOaLocation W29915763051 @default.
• W2991576305 hasConcept C104317684 @default.
• W2991576305 hasConcept C126322002 @default.
• W2991576305 hasConcept C142724271 @default.
• W2991576305 hasConcept C150194340 @default.
• W2991576305 hasConcept C190727270 @default.
• W2991576305 hasConcept C2777302934 @default.
• W2991576305 hasConcept C2777439022 @default.
• W2991576305 hasConcept C3017910909 @default.
• W2991576305 hasConcept C33288867 @default.
• W2991576305 hasConcept C54355233 @default.
• W2991576305 hasConcept C58471807 @default.
• W2991576305 hasConcept C71924100 @default.
• W2991576305 hasConcept C86339819 @default.
• W2991576305 hasConcept C86803240 @default.
• W2991576305 hasConcept C90924648 @default.
• W2991576305 hasConceptScore W2991576305C104317684 @default.
• W2991576305 hasConceptScore W2991576305C126322002 @default.
• W2991576305 hasConceptScore W2991576305C142724271 @default.
• W2991576305 hasConceptScore W2991576305C150194340 @default.
• W2991576305 hasConceptScore W2991576305C190727270 @default.
• W2991576305 hasConceptScore W2991576305C2777302934 @default.
• W2991576305 hasConceptScore W2991576305C2777439022 @default.
• W2991576305 hasConceptScore W2991576305C3017910909 @default.
• W2991576305 hasConceptScore W2991576305C33288867 @default.
• W2991576305 hasConceptScore W2991576305C54355233 @default.
• W2991576305 hasConceptScore W2991576305C58471807 @default.
• W2991576305 hasConceptScore W2991576305C71924100 @default.
• W2991576305 hasConceptScore W2991576305C86339819 @default.
• W2991576305 hasConceptScore W2991576305C86803240 @default.
• W2991576305 hasConceptScore W2991576305C90924648 @default.
• W2991576305 hasIssue "12" @default.
• W2991576305 hasLocation W29915763051 @default.
• W2991576305 hasLocation W29915763052 @default.
• W2991576305 hasLocation W29915763053 @default.
• W2991576305 hasLocation W29915763054 @default.
• W2991576305 hasOpenAccess W2991576305 @default.
• W2991576305 hasPrimaryLocation W29915763051 @default.

• next