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• W2991640995 abstract "Many conditions affecting the heart, brain and even the eyes have their origin on blood vessel pathology, underscoring the role of vascular regulation. In age-related macular degeneration (AMD), there is excessive growth of abnormal blood vessels in the eye (choroidal neovascularization), eventually leading to vision loss due to detachment of retinal pigmented epithelium. As the advanced stage of this disease involves loss of retinal pigmented epithelium, much less attention has been given to early vascular events such as endothelial dysfunction. Although current gold standard therapy using inhibitors of vascular endothelial growth factor (VEGF) have achieved initial successes, some drawbacks include the lack of long-term restoration of visual acuity, as well as a subset of the patients being refractory to existing treatment, alluding us and others to hypothesize upon VEGF-independent mechanisms. Against this backdrop, we present here a non-exhaustive review on the vascular underpinnings of AMD, implications with genetic and systemic factors, experimental models for studying choroidal neovascularization, and interestingly, on both endothelial-centric pathways and non-cell autonomous mechanisms. We hope to shed light on future research directions in improving vascular function in ocular disorders." @default.
• W2991640995 created "2019-12-05" @default.
• W2991640995 creator A5007228843 @default.
• W2991640995 creator A5015003756 @default.
• W2991640995 creator A5072498146 @default.
• W2991640995 date "2019-11-29" @default.
• W2991640995 modified "2023-10-10" @default.
• W2991640995 title "Choroidal Neovascularization: Mechanisms of Endothelial Dysfunction" @default.
• W2991640995 cites W1223351957 @default.
• W2991640995 cites W1436283894 @default.
• W2991640995 cites W1481978003 @default.
• W2991640995 cites W1487528435 @default.
• W2991640995 cites W1544345685 @default.
• W2991640995 cites W1546928690 @default.
• W2991640995 cites W1553154837 @default.
• W2991640995 cites W1554077695 @default.
• W2991640995 cites W157692930 @default.
• W2991640995 cites W1581940649 @default.
• W2991640995 cites W1599915172 @default.
• W2991640995 cites W1670632949 @default.
• W2991640995 cites W168181582 @default.
• W2991640995 cites W1707478454 @default.
• W2991640995 cites W1780202576 @default.
• W2991640995 cites W1813781971 @default.
• W2991640995 cites W1828637420 @default.
• W2991640995 cites W1829927964 @default.
• W2991640995 cites W183147717 @default.
• W2991640995 cites W1901360874 @default.
• W2991640995 cites W1963528303 @default.
• W2991640995 cites W1964287112 @default.
• W2991640995 cites W1964802599 @default.
• W2991640995 cites W1964866355 @default.
• W2991640995 cites W1965972308 @default.
• W2991640995 cites W1968375701 @default.
• W2991640995 cites W1969364068 @default.
• W2991640995 cites W1970743033 @default.
• W2991640995 cites W1974556922 @default.
• W2991640995 cites W1975111610 @default.
• W2991640995 cites W1976704017 @default.
• W2991640995 cites W1977327764 @default.
• W2991640995 cites W1977532338 @default.
• W2991640995 cites W1978427224 @default.
• W2991640995 cites W1978566888 @default.
• W2991640995 cites W1978913875 @default.
• W2991640995 cites W1978924431 @default.
• W2991640995 cites W1980748384 @default.
• W2991640995 cites W1982572468 @default.
• W2991640995 cites W1985386407 @default.
• W2991640995 cites W1985388968 @default.
• W2991640995 cites W1988516817 @default.
• W2991640995 cites W1989143262 @default.
• W2991640995 cites W1989957765 @default.
• W2991640995 cites W1991934654 @default.
• W2991640995 cites W1993089936 @default.
• W2991640995 cites W1993419164 @default.
• W2991640995 cites W1995085615 @default.
• W2991640995 cites W1996608135 @default.
• W2991640995 cites W1996715032 @default.
• W2991640995 cites W1997920896 @default.
• W2991640995 cites W1998100932 @default.
• W2991640995 cites W2001609725 @default.
• W2991640995 cites W2002123695 @default.
• W2991640995 cites W2004599279 @default.
• W2991640995 cites W2004778795 @default.
• W2991640995 cites W2007014682 @default.
• W2991640995 cites W2008505031 @default.
• W2991640995 cites W2010486643 @default.
• W2991640995 cites W2010880469 @default.
• W2991640995 cites W2011393181 @default.
• W2991640995 cites W2012322597 @default.
• W2991640995 cites W2013800293 @default.
• W2991640995 cites W2015439810 @default.
• W2991640995 cites W2021094520 @default.
• W2991640995 cites W2021311336 @default.
• W2991640995 cites W2024460795 @default.
• W2991640995 cites W2024524941 @default.
• W2991640995 cites W2025128457 @default.
• W2991640995 cites W2025313923 @default.
• W2991640995 cites W2025806325 @default.
• W2991640995 cites W2029229239 @default.
• W2991640995 cites W2030956577 @default.
• W2991640995 cites W2034110220 @default.
• W2991640995 cites W2035310463 @default.
• W2991640995 cites W2038687662 @default.
• W2991640995 cites W2038816180 @default.
• W2991640995 cites W2041555469 @default.
• W2991640995 cites W2041555699 @default.
• W2991640995 cites W2042158814 @default.
• W2991640995 cites W2042818357 @default.
• W2991640995 cites W2044650785 @default.
• W2991640995 cites W2045786338 @default.
• W2991640995 cites W2049727981 @default.
• W2991640995 cites W2052322361 @default.
• W2991640995 cites W2052397130 @default.
• W2991640995 cites W2052826267 @default.
• W2991640995 cites W2053704719 @default.
• W2991640995 cites W2054864390 @default.
• W2991640995 cites W2055153760 @default.
• W2991640995 cites W2055522471 @default.
• W2991640995 cites W2056044648 @default.

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