Matches in SemOpenAlex for { <https://semopenalex.org/work/W2991647438> ?p ?o ?g. }
- W2991647438 endingPage "62.e5" @default.
- W2991647438 startingPage "54" @default.
- W2991647438 abstract "Epidermal growth factor receptors (EGFRs) are central cellular signaling interfaces whose misregulation is related to several severe diseases. Although ligand binding to the extracellular domain is the most obvious regulatory element, also intracellular factors can act as modulators of EGFR activity. The juxtamembrane (JM) segment seems to be the receptor's key interaction interface of these cytoplasmic factors. However, only a limited number of cytoplasmic EGFR modulators are known and a comprehensive understanding of their mode of action is lacking. Here, we report ARNO, a member of the cytohesin family, as another JM-binding protein and structurally characterize the ARNO-EGFR interaction interface. We reveal that its binding mode displays common features and distinct differences with JM's interaction with calmodulin and anionic phospholipids. Furthermore, we show that each interaction can be modulated by additional factors, generating a distinctly regulated network of possible EGFR modulators acting on the intracellular domain of the receptor." @default.
- W2991647438 created "2019-12-05" @default.
- W2991647438 creator A5000716657 @default.
- W2991647438 creator A5050536439 @default.
- W2991647438 creator A5055435399 @default.
- W2991647438 creator A5060774311 @default.
- W2991647438 creator A5074400980 @default.
- W2991647438 creator A5076636733 @default.
- W2991647438 creator A5078752390 @default.
- W2991647438 creator A5087269440 @default.
- W2991647438 date "2020-01-01" @default.
- W2991647438 modified "2023-10-10" @default.
- W2991647438 title "Molecular Architecture of a Network of Potential Intracellular EGFR Modulators: ARNO, CaM, Phospholipids, and the Juxtamembrane Segment" @default.
- W2991647438 cites W1553799143 @default.
- W2991647438 cites W1568614184 @default.
- W2991647438 cites W1583107506 @default.
- W2991647438 cites W1598629441 @default.
- W2991647438 cites W1673824819 @default.
- W2991647438 cites W1739486953 @default.
- W2991647438 cites W1967679941 @default.
- W2991647438 cites W1968013329 @default.
- W2991647438 cites W1973615656 @default.
- W2991647438 cites W1976339699 @default.
- W2991647438 cites W1982195246 @default.
- W2991647438 cites W1982598441 @default.
- W2991647438 cites W1992144784 @default.
- W2991647438 cites W1995242599 @default.
- W2991647438 cites W2002856612 @default.
- W2991647438 cites W2005574282 @default.
- W2991647438 cites W2010030578 @default.
- W2991647438 cites W2016052537 @default.
- W2991647438 cites W2018170084 @default.
- W2991647438 cites W2031325295 @default.
- W2991647438 cites W2031591057 @default.
- W2991647438 cites W2035713281 @default.
- W2991647438 cites W2037299149 @default.
- W2991647438 cites W2037635704 @default.
- W2991647438 cites W2041577222 @default.
- W2991647438 cites W2041745716 @default.
- W2991647438 cites W2043771545 @default.
- W2991647438 cites W2045709340 @default.
- W2991647438 cites W2050046701 @default.
- W2991647438 cites W2055841589 @default.
- W2991647438 cites W2059715478 @default.
- W2991647438 cites W2064728674 @default.
- W2991647438 cites W2069602336 @default.
- W2991647438 cites W2073574973 @default.
- W2991647438 cites W2082477555 @default.
- W2991647438 cites W2084482399 @default.
- W2991647438 cites W2088848851 @default.
- W2991647438 cites W2090222587 @default.
- W2991647438 cites W2099203391 @default.
- W2991647438 cites W2100794900 @default.
- W2991647438 cites W2113781743 @default.
- W2991647438 cites W2114135515 @default.
- W2991647438 cites W2121467196 @default.
- W2991647438 cites W2136343696 @default.
- W2991647438 cites W2143293886 @default.
- W2991647438 cites W2146601173 @default.
- W2991647438 cites W2325225043 @default.
- W2991647438 cites W2417505470 @default.
- W2991647438 cites W2518759821 @default.
- W2991647438 cites W2735337561 @default.
- W2991647438 cites W2766352488 @default.
- W2991647438 cites W2802849544 @default.
- W2991647438 cites W2898050913 @default.
- W2991647438 cites W4300789395 @default.
- W2991647438 doi "https://doi.org/10.1016/j.str.2019.11.001" @default.
- W2991647438 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31780432" @default.
- W2991647438 hasPublicationYear "2020" @default.
- W2991647438 type Work @default.
- W2991647438 sameAs 2991647438 @default.
- W2991647438 citedByCount "8" @default.
- W2991647438 countsByYear W29916474382020 @default.
- W2991647438 countsByYear W29916474382021 @default.
- W2991647438 countsByYear W29916474382022 @default.
- W2991647438 countsByYear W29916474382023 @default.
- W2991647438 crossrefType "journal-article" @default.
- W2991647438 hasAuthorship W2991647438A5000716657 @default.
- W2991647438 hasAuthorship W2991647438A5050536439 @default.
- W2991647438 hasAuthorship W2991647438A5055435399 @default.
- W2991647438 hasAuthorship W2991647438A5060774311 @default.
- W2991647438 hasAuthorship W2991647438A5074400980 @default.
- W2991647438 hasAuthorship W2991647438A5076636733 @default.
- W2991647438 hasAuthorship W2991647438A5078752390 @default.
- W2991647438 hasAuthorship W2991647438A5087269440 @default.
- W2991647438 hasBestOaLocation W29916474381 @default.
- W2991647438 hasConcept C107824862 @default.
- W2991647438 hasConcept C11804247 @default.
- W2991647438 hasConcept C121587506 @default.
- W2991647438 hasConcept C12554922 @default.
- W2991647438 hasConcept C170493617 @default.
- W2991647438 hasConcept C181199279 @default.
- W2991647438 hasConcept C190062978 @default.
- W2991647438 hasConcept C2779438470 @default.
- W2991647438 hasConcept C28406088 @default.
- W2991647438 hasConcept C29688787 @default.
- W2991647438 hasConcept C51639874 @default.