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- W2991718260 abstract "Abstract Neuropsychiatric disorders have long been known to have a strong genetic component, but until about 10 years ago, their molecular pathology was largely unknown. A greater understanding of the genetic risk underlying these conditions was driven by advances in microarray and sequencing technologies and large-scale genome-wide association studies. We now know that these disorders are highly polygenic, and common risk alleles at multiple loci have been associated with schizophrenia (SZ), bipolar disorder, and major depression. Thirteen large, rare copy number variants (CNVs) have been confidently implicated in SZ, although their role in bipolar disorder and depression is much smaller. High-throughput sequencing studies in patients with SZ have shown rare coding variants to be enriched among neuronally expressed genes, such as the activity-regulated cytoskeleton-associated protein and N-methyl- d -aspartate receptor synaptic protein complexes. Cross-disorder studies have also indicated a strong genetic overlap between various neuropsychiatric disorders." @default.
- W2991718260 created "2019-12-13" @default.
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- W2991718260 date "2020-01-01" @default.
- W2991718260 modified "2023-09-25" @default.
- W2991718260 title "Molecular pathology in neuropsychiatric disorders" @default.
- W2991718260 doi "https://doi.org/10.1016/b978-0-12-809356-6.00028-9" @default.
- W2991718260 hasPublicationYear "2020" @default.
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