FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2991735893> ?p ?o ?g. }

• W2991735893 endingPage "879" @default.
• W2991735893 startingPage "871" @default.
• W2991735893 abstract "BackgroundAmoxicillin has been in use since the 1970s; it is the most widely used penicillin both alone and in combination with the β-lactamase clavulanic acid.ObjectivesIn this narrative review, we re-examine the properties of oral amoxicillin and clavulanic acid and provide guidance on their use, with emphasis on the preferred use of amoxicillin alone.SourcesPublished medical literature (MEDLINE database via Pubmed).ContentWhile amoxicillin and clavulanic acid have similar half-lives, clavulanic acid is more protein bound and even less heat stable than amoxicillin, with primarily hepatic metabolism. It is also more strongly associated with gastrointestinal side effects, including Clostridium difficile infection, and, thus, in oral combination formulations, limits the maximum daily dose of amoxicillin that can be given. The first ratio for an amoxicillin–clavulanic acid combination was set at 4:1 due to clavulanic acid's high affinity for β-lactamases; ratios of 2:1, 7:1, 14:1 and 16:1 are currently available in various regions. Comparative effectiveness data for the different ratios are scarce. Amoxicillin–clavulanic acid is often used as empiric therapy for many of the World Health Organization's Priority Infectious Syndromes in adults and children, leading to extensive consumption, when some of these syndromes could be handled with a delayed antibiotic prescription approach or amoxicillin alone.ImplicationsUsing available epidemiological and pharmacokinetic data, we provide guidance on indications for amoxicillin versus amoxicillin–clavulanic acid and on optimal oral administration, including choice of combination ratio. More data are needed, particularly on heat stability, pharmacodynamic effects and emergence of resistance in ‘real-world’ clinical settings." @default.
• W2991735893 created "2019-12-13" @default.
• W2991735893 creator A5002934725 @default.
• W2991735893 creator A5012419223 @default.
• W2991735893 creator A5047108361 @default.
• W2991735893 creator A5062909007 @default.
• W2991735893 creator A5069262777 @default.
• W2991735893 creator A5072267498 @default.
• W2991735893 creator A5077051125 @default.
• W2991735893 date "2020-07-01" @default.
• W2991735893 modified "2023-10-10" @default.
• W2991735893 title "Oral amoxicillin and amoxicillin–clavulanic acid: properties, indications and usage" @default.
• W2991735893 cites W1755931663 @default.
• W2991735893 cites W176083338 @default.
• W2991735893 cites W1772038480 @default.
• W2991735893 cites W1793465640 @default.
• W2991735893 cites W1964254101 @default.
• W2991735893 cites W1969572602 @default.
• W2991735893 cites W1970224258 @default.
• W2991735893 cites W1979594041 @default.
• W2991735893 cites W1981750002 @default.
• W2991735893 cites W1993864236 @default.
• W2991735893 cites W1996184208 @default.
• W2991735893 cites W1996960109 @default.
• W2991735893 cites W1997904288 @default.
• W2991735893 cites W2000714505 @default.
• W2991735893 cites W2012564721 @default.
• W2991735893 cites W2013112438 @default.
• W2991735893 cites W2013716233 @default.
• W2991735893 cites W2015979923 @default.
• W2991735893 cites W2018838056 @default.
• W2991735893 cites W2019067140 @default.
• W2991735893 cites W2021159907 @default.
• W2991735893 cites W2029144266 @default.
• W2991735893 cites W2032387030 @default.
• W2991735893 cites W2037232200 @default.
• W2991735893 cites W2053129457 @default.
• W2991735893 cites W2054173017 @default.
• W2991735893 cites W2055135288 @default.
• W2991735893 cites W2065254807 @default.
• W2991735893 cites W2074738667 @default.
• W2991735893 cites W2077028134 @default.
• W2991735893 cites W2080394999 @default.
• W2991735893 cites W2088021352 @default.
• W2991735893 cites W2090817344 @default.
• W2991735893 cites W2094111345 @default.
• W2991735893 cites W2095741521 @default.
• W2991735893 cites W2096489042 @default.
• W2991735893 cites W2098666638 @default.
• W2991735893 cites W2099341283 @default.
• W2991735893 cites W2102208951 @default.
• W2991735893 cites W2102648753 @default.
• W2991735893 cites W2104628878 @default.
• W2991735893 cites W2105212782 @default.
• W2991735893 cites W2105543037 @default.
• W2991735893 cites W2108823677 @default.
• W2991735893 cites W2109732641 @default.
• W2991735893 cites W2109921630 @default.
• W2991735893 cites W2115185158 @default.
• W2991735893 cites W2119658374 @default.
• W2991735893 cites W212246948 @default.
• W2991735893 cites W2129592318 @default.
• W2991735893 cites W2129636343 @default.
• W2991735893 cites W2130878548 @default.
• W2991735893 cites W2136483279 @default.
• W2991735893 cites W2139375784 @default.
• W2991735893 cites W2143874510 @default.
• W2991735893 cites W2158718403 @default.
• W2991735893 cites W2163197070 @default.
• W2991735893 cites W2170582243 @default.
• W2991735893 cites W2181015250 @default.
• W2991735893 cites W2270943729 @default.
• W2991735893 cites W2326811217 @default.
• W2991735893 cites W2343187398 @default.
• W2991735893 cites W2461495609 @default.
• W2991735893 cites W2471913318 @default.
• W2991735893 cites W2475845335 @default.
• W2991735893 cites W2581692974 @default.
• W2991735893 cites W2585355945 @default.
• W2991735893 cites W2624421651 @default.
• W2991735893 cites W2751307740 @default.
• W2991735893 cites W2766854211 @default.
• W2991735893 cites W2767489815 @default.
• W2991735893 cites W2768067960 @default.
• W2991735893 cites W2768715906 @default.
• W2991735893 cites W2779087618 @default.
• W2991735893 cites W2798135673 @default.
• W2991735893 cites W2799347337 @default.
• W2991735893 cites W2807674603 @default.
• W2991735893 cites W2914625246 @default.
• W2991735893 cites W2919983824 @default.
• W2991735893 cites W2950530098 @default.
• W2991735893 cites W2960092777 @default.
• W2991735893 cites W4210321301 @default.
• W2991735893 cites W91579775 @default.
• W2991735893 cites W956391100 @default.
• W2991735893 doi "https://doi.org/10.1016/j.cmi.2019.11.028" @default.
• W2991735893 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31811919" @default.

• next