Matches in SemOpenAlex for { <https://semopenalex.org/work/W2991836667> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W2991836667 endingPage "299" @default.
- W2991836667 startingPage "295" @default.
- W2991836667 abstract "Shortened telomeres were found in patients with cirrhosis, probably reflecting chronic liver injury, continuous regeneration, and destruction of hepatic nodules.To test whether telomere shortening is a general marker of cirrhosis, independent of disease etiology.We evaluated telomere length in patients with cryptogenic cirrhosis (largely a late sequela of steatohepatitis) compared to patients with cirrhosis caused by chronic hepatitis B and C (HBV/HCV). We also evaluated telomere aggregates, a sensitive parameter of telomere dysfunction and genetic instability. We analyzed peripheral lymphocytes from 25 patients with cryptogenic cirrhosis, 15 patients with cirrhosis due to chronic viral hepatitis, and 20 age-matched controls. Telomere length was analyzed using quantitative fluorescence in situ hybridization. Aggregate size was divided into three fusion groups of 2-5, 6-10, and 11-15 telomeres, relative to the size of a single telomere.Shorter telomere length was found in patients with cirrhosis from all three etiologies (mean 121.3 ± 24.1) compared to controls (mean 63.5 ± 23.5). In contrast, there was significantly more fusion of > 5 telomeres only in the HBV/HCV cirrhosis group compared to healthy controls (P = 0.023), but not in the cryptogenic cirrhosis group.While shortened telomeres in peripheral lymphocytes are a general marker of liver cirrhosis, telomere aggregates may signify a more sensitive genetic instability parameter for the diverse, etiology-based malignant potential of cirrhosis. This finding is in agreement with the well-known higher tendency toward developing hepatocellular carcinoma with cirrhosis caused by chronic hepatitis relative to steatohepatitis." @default.
- W2991836667 created "2019-12-13" @default.
- W2991836667 creator A5006760751 @default.
- W2991836667 creator A5046854414 @default.
- W2991836667 creator A5068404015 @default.
- W2991836667 creator A5070574102 @default.
- W2991836667 creator A5080364844 @default.
- W2991836667 creator A5084081073 @default.
- W2991836667 creator A5084409289 @default.
- W2991836667 date "2018-05-01" @default.
- W2991836667 modified "2023-09-23" @default.
- W2991836667 title "Telomere Length, Aggregates, and Capture in Cirrhosis." @default.
- W2991836667 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29761675" @default.
- W2991836667 hasPublicationYear "2018" @default.
- W2991836667 type Work @default.
- W2991836667 sameAs 2991836667 @default.
- W2991836667 citedByCount "0" @default.
- W2991836667 crossrefType "journal-article" @default.
- W2991836667 hasAuthorship W2991836667A5006760751 @default.
- W2991836667 hasAuthorship W2991836667A5046854414 @default.
- W2991836667 hasAuthorship W2991836667A5068404015 @default.
- W2991836667 hasAuthorship W2991836667A5070574102 @default.
- W2991836667 hasAuthorship W2991836667A5080364844 @default.
- W2991836667 hasAuthorship W2991836667A5084081073 @default.
- W2991836667 hasAuthorship W2991836667A5084409289 @default.
- W2991836667 hasConcept C126322002 @default.
- W2991836667 hasConcept C142724271 @default.
- W2991836667 hasConcept C177336024 @default.
- W2991836667 hasConcept C2776455275 @default.
- W2991836667 hasConcept C2777214474 @default.
- W2991836667 hasConcept C2778019345 @default.
- W2991836667 hasConcept C54355233 @default.
- W2991836667 hasConcept C552990157 @default.
- W2991836667 hasConcept C71924100 @default.
- W2991836667 hasConcept C86803240 @default.
- W2991836667 hasConcept C90924648 @default.
- W2991836667 hasConceptScore W2991836667C126322002 @default.
- W2991836667 hasConceptScore W2991836667C142724271 @default.
- W2991836667 hasConceptScore W2991836667C177336024 @default.
- W2991836667 hasConceptScore W2991836667C2776455275 @default.
- W2991836667 hasConceptScore W2991836667C2777214474 @default.
- W2991836667 hasConceptScore W2991836667C2778019345 @default.
- W2991836667 hasConceptScore W2991836667C54355233 @default.
- W2991836667 hasConceptScore W2991836667C552990157 @default.
- W2991836667 hasConceptScore W2991836667C71924100 @default.
- W2991836667 hasConceptScore W2991836667C86803240 @default.
- W2991836667 hasConceptScore W2991836667C90924648 @default.
- W2991836667 hasIssue "5" @default.
- W2991836667 hasLocation W29918366671 @default.
- W2991836667 hasOpenAccess W2991836667 @default.
- W2991836667 hasPrimaryLocation W29918366671 @default.
- W2991836667 hasRelatedWork W1970981804 @default.
- W2991836667 hasRelatedWork W2033489395 @default.
- W2991836667 hasRelatedWork W2061799564 @default.
- W2991836667 hasRelatedWork W2324406516 @default.
- W2991836667 hasRelatedWork W2347335137 @default.
- W2991836667 hasRelatedWork W2356918548 @default.
- W2991836667 hasRelatedWork W2371034248 @default.
- W2991836667 hasRelatedWork W2392233792 @default.
- W2991836667 hasRelatedWork W3030616408 @default.
- W2991836667 hasRelatedWork W3091367366 @default.
- W2991836667 hasVolume "20" @default.
- W2991836667 isParatext "false" @default.
- W2991836667 isRetracted "false" @default.
- W2991836667 magId "2991836667" @default.
- W2991836667 workType "article" @default.