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- W2991837454 endingPage "2979" @default.
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- W2991837454 abstract "Abstract: Pro-inflammatory hormones and cytokines (leptin, tumor necrosis factor (TNF)-α, and interleukin (IL)-6) rise in obesity. Elevated levels of hormones and cytokines are linked with several comorbidities such as diabetes, heart disease, and cancer. The checkpoint programmed cell death protein 1 (PD-1)/programmed death-ligand 1 (PD-L1) plays an important role in obesity and cancer proliferation. L-thyroxine (T4) and steroid hormones up-regulate PD-L1 accumulation and promote inflammation in cancer cells and diabetics. On the other hand, resveratrol and other herbal medicines suppress PD-L1 accumulation and reduce diabetic effects. In addition, they induce anti-cancer proliferation in various types of cancer cells via different mechanisms. In the current review, we discuss new findings and visions into the antagonizing effects of hormones on herbal medicine-induced anti-cancer properties." @default.
- W2991837454 created "2019-12-13" @default.
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- W2991837454 date "2019-12-05" @default.
- W2991837454 modified "2023-09-25" @default.
- W2991837454 title "Herbal Medicines Attenuate PD-L1 Expression to Induce Anti-Proliferation in Obesity-Related Cancers" @default.
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- W2991837454 doi "https://doi.org/10.3390/nu11122979" @default.
- W2991837454 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6949899" @default.
- W2991837454 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31817534" @default.
- W2991837454 hasPublicationYear "2019" @default.
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