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- W2991864245 abstract "Abstract Throughout the animal kingdom, the structure of the central nervous system varies widely from distributed ganglia in worms to compact brains with varying degrees of folding in mammals. The differences in structure may indicate a fundamentally different circuit organization. However, the folded brain most likely is a direct result of mechanical forces when considering that a larger surface area of cortex packs into the restricted volume provided by the skull. Here, we introduce a computational model that instead of modeling mechanical forces relies on dimension reduction methods to place neurons according to specific connectivity requirements. For a simplified connectivity with strong local and weak long-range connections, our model predicts a transition from separate ganglia through smooth brain structures to heavily folded brains as the number of cortical columns increases. The model reproduces experimentally determined relationships between metrics of cortical folding and its pathological phenotypes in lissencephaly, polymicrogyria, microcephaly, autism, and schizophrenia. This suggests that mechanical forces that are known to lead to cortical folding may synergistically contribute to arrangements that reduce wiring. Our model provides a unified conceptual understanding of gyrification linking cellular connectivity and macroscopic structures in large-scale neural network models of the brain." @default.
- W2991864245 created "2019-12-13" @default.
- W2991864245 creator A5000685798 @default.
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- W2991864245 creator A5046801422 @default.
- W2991864245 creator A5059626898 @default.
- W2991864245 creator A5065703786 @default.
- W2991864245 date "2019-12-06" @default.
- W2991864245 modified "2023-10-17" @default.
- W2991864245 title "A Model of Brain Folding Based on Strong Local and Weak Long-Range Connectivity Requirements" @default.
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