Matches in SemOpenAlex for { <https://semopenalex.org/work/W2991907539> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2991907539 endingPage "21" @default.
- W2991907539 startingPage "14" @default.
- W2991907539 abstract "Objective: Felodipine is a calcium channel blocker used for hypertensive and unstable angina treatments. The sustained release formulations of felodipine have advantages of achieving good therapeutic effects, increasing a bioavailability, decreasing dosing times per day and reducing side effects. The aim of our study was to study the formulation screening, then use an experiment design for formulating a hydrophilic matrix sustained release Tablet of felodipine. Methods: The optimization process had the influences of the chosen excipients (including HPMC E4M, HPMC E15LV) on the drug release. Three dependent variables were percentages of released felodipine at the sampling times 2 h, 6 h, 10 h (Y2, Y6, Y10, respectively). Results: The release profile from the optimized formula almost met the predicted release profile and similar to reference Tablets. The kinetics of drug release the optimized Tablets and reference Tablets were also followed the Korsmeyer-Peppas model. Conclusion: The optimized formula was obtained, and the in vitro release profile was similar to the predicted profile and reference Tablets." @default.
- W2991907539 created "2019-12-13" @default.
- W2991907539 creator A5013711127 @default.
- W2991907539 creator A5038064825 @default.
- W2991907539 creator A5044964592 @default.
- W2991907539 creator A5058691218 @default.
- W2991907539 creator A5066564841 @default.
- W2991907539 date "2018-01-01" @default.
- W2991907539 modified "2023-09-26" @default.
- W2991907539 title "Applying Experimental Design and Optimization of Studying the Hydrophilic Matrix Sustained-Release Tablets of Felodipine" @default.
- W2991907539 cites W100367594 @default.
- W2991907539 cites W2061640842 @default.
- W2991907539 cites W2071060910 @default.
- W2991907539 cites W2229494918 @default.
- W2991907539 hasPublicationYear "2018" @default.
- W2991907539 type Work @default.
- W2991907539 sameAs 2991907539 @default.
- W2991907539 citedByCount "0" @default.
- W2991907539 crossrefType "journal-article" @default.
- W2991907539 hasAuthorship W2991907539A5013711127 @default.
- W2991907539 hasAuthorship W2991907539A5038064825 @default.
- W2991907539 hasAuthorship W2991907539A5044964592 @default.
- W2991907539 hasAuthorship W2991907539A5058691218 @default.
- W2991907539 hasAuthorship W2991907539A5066564841 @default.
- W2991907539 hasConcept C106487976 @default.
- W2991907539 hasConcept C126838900 @default.
- W2991907539 hasConcept C181389837 @default.
- W2991907539 hasConcept C185592680 @default.
- W2991907539 hasConcept C2780648877 @default.
- W2991907539 hasConcept C3019981671 @default.
- W2991907539 hasConcept C43617362 @default.
- W2991907539 hasConcept C71924100 @default.
- W2991907539 hasConcept C84393581 @default.
- W2991907539 hasConcept C98274493 @default.
- W2991907539 hasConceptScore W2991907539C106487976 @default.
- W2991907539 hasConceptScore W2991907539C126838900 @default.
- W2991907539 hasConceptScore W2991907539C181389837 @default.
- W2991907539 hasConceptScore W2991907539C185592680 @default.
- W2991907539 hasConceptScore W2991907539C2780648877 @default.
- W2991907539 hasConceptScore W2991907539C3019981671 @default.
- W2991907539 hasConceptScore W2991907539C43617362 @default.
- W2991907539 hasConceptScore W2991907539C71924100 @default.
- W2991907539 hasConceptScore W2991907539C84393581 @default.
- W2991907539 hasConceptScore W2991907539C98274493 @default.
- W2991907539 hasIssue "64" @default.
- W2991907539 hasLocation W29919075391 @default.
- W2991907539 hasOpenAccess W2991907539 @default.
- W2991907539 hasPrimaryLocation W29919075391 @default.
- W2991907539 hasRelatedWork W2011365009 @default.
- W2991907539 hasRelatedWork W2128959335 @default.
- W2991907539 hasRelatedWork W2141921813 @default.
- W2991907539 hasRelatedWork W2171074395 @default.
- W2991907539 hasRelatedWork W2247069502 @default.
- W2991907539 hasRelatedWork W2329211369 @default.
- W2991907539 hasRelatedWork W2352162805 @default.
- W2991907539 hasRelatedWork W2408632589 @default.
- W2991907539 hasRelatedWork W2489784639 @default.
- W2991907539 hasRelatedWork W2593718295 @default.
- W2991907539 hasRelatedWork W2899872068 @default.
- W2991907539 hasRelatedWork W2912688304 @default.
- W2991907539 hasRelatedWork W2114836135 @default.
- W2991907539 hasRelatedWork W2154542627 @default.
- W2991907539 hasRelatedWork W2184089370 @default.
- W2991907539 hasRelatedWork W2186548518 @default.
- W2991907539 hasRelatedWork W2189233654 @default.
- W2991907539 hasRelatedWork W2605344327 @default.
- W2991907539 hasRelatedWork W3146016168 @default.
- W2991907539 hasRelatedWork W3147470068 @default.
- W2991907539 hasVolume "8" @default.
- W2991907539 isParatext "false" @default.
- W2991907539 isRetracted "false" @default.
- W2991907539 magId "2991907539" @default.
- W2991907539 workType "article" @default.