FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2991998463> ?p ?o ?g. }

• W2991998463 endingPage "674" @default.
• W2991998463 startingPage "666" @default.
• W2991998463 abstract "Abstract Abnormal neuroanatomic brain networks have been reported in schizophrenia, but their characterization across patients with psychotic disorders, and their potential alterations in nonpsychotic relatives, remain to be clarified. Participants recruited by the Bipolar and Schizophrenia Network for Intermediate Phenotypes consortium included 326 probands with psychotic disorders (107 with schizophrenia (SZ), 87 with schizoaffective disorder (SAD), 132 with psychotic bipolar disorder (BD)), 315 of their nonpsychotic first-degree relatives and 202 healthy controls. Single-subject gray matter graphs were extracted from structural MRI scans, and whole-brain neuroanatomic organization was compared across the participant groups. Compared with healthy controls, psychotic probands showed decreased nodal efficiency mainly in bilateral superior temporal regions. These regions had altered morphological relationships primarily with frontal lobe regions, and their network-level alterations were associated with positive symptoms of psychosis. Nonpsychotic relatives showed lower nodal centrality metrics in the prefrontal cortex and subcortical regions, and higher nodal centrality metrics in the left cingulate cortex and left thalamus. Diagnosis-specific analysis indicated that individuals with SZ had lower nodal efficiency in bilateral superior temporal regions than controls, probands with SAD only exhibited lower nodal efficiency in the left superior and middle temporal gyrus, and individuals with psychotic BD did not show significant differences from healthy controls. Our findings provide novel evidence of clinically relevant disruptions in the anatomic association of the superior temporal lobe with other regions of whole-brain networks in patients with psychotic disorders, but not in their unaffected relatives, suggesting that it is a disease-related trait. Network disorganization primarily involving frontal lobe and subcortical regions in nonpsychotic relatives may be related to familial illness risk." @default.
• W2991998463 created "2019-12-13" @default.
• W2991998463 creator A5000706062 @default.
• W2991998463 creator A5004848485 @default.
• W2991998463 creator A5008731253 @default.
• W2991998463 creator A5010729829 @default.
• W2991998463 creator A5011715160 @default.
• W2991998463 creator A5016253872 @default.
• W2991998463 creator A5023252875 @default.
• W2991998463 creator A5029129951 @default.
• W2991998463 creator A5033047276 @default.
• W2991998463 creator A5042537712 @default.
• W2991998463 creator A5044496202 @default.
• W2991998463 creator A5051538064 @default.
• W2991998463 creator A5055924112 @default.
• W2991998463 creator A5058853115 @default.
• W2991998463 creator A5091162498 @default.
• W2991998463 date "2019-12-07" @default.
• W2991998463 modified "2023-10-15" @default.
• W2991998463 title "Brain gray matter network organization in psychotic disorders" @default.
• W2991998463 cites W1492064281 @default.
• W2991998463 cites W1850248061 @default.
• W2991998463 cites W1974764791 @default.
• W2991998463 cites W1984944505 @default.
• W2991998463 cites W1986094520 @default.
• W2991998463 cites W1990087745 @default.
• W2991998463 cites W1994239403 @default.
• W2991998463 cites W1999653836 @default.
• W2991998463 cites W2005933475 @default.
• W2991998463 cites W2007298996 @default.
• W2991998463 cites W2009650955 @default.
• W2991998463 cites W2014022174 @default.
• W2991998463 cites W2019813370 @default.
• W2991998463 cites W2020575476 @default.
• W2991998463 cites W2040356271 @default.
• W2991998463 cites W2041198871 @default.
• W2991998463 cites W2044829843 @default.
• W2991998463 cites W2052805526 @default.
• W2991998463 cites W2053533857 @default.
• W2991998463 cites W2056081184 @default.
• W2991998463 cites W2057210430 @default.
• W2991998463 cites W2058046532 @default.
• W2991998463 cites W2058087702 @default.
• W2991998463 cites W2060080559 @default.
• W2991998463 cites W2060464767 @default.
• W2991998463 cites W2076380208 @default.
• W2991998463 cites W2081828863 @default.
• W2991998463 cites W2084009541 @default.
• W2991998463 cites W2100570947 @default.
• W2991998463 cites W2102108192 @default.
• W2991998463 cites W2107489392 @default.
• W2991998463 cites W2107807525 @default.
• W2991998463 cites W2108930593 @default.
• W2991998463 cites W2109866764 @default.
• W2991998463 cites W2112090702 @default.
• W2991998463 cites W2125576000 @default.
• W2991998463 cites W2126838454 @default.
• W2991998463 cites W2127070446 @default.
• W2991998463 cites W2131823335 @default.
• W2991998463 cites W2133015986 @default.
• W2991998463 cites W2134212997 @default.
• W2991998463 cites W2134630800 @default.
• W2991998463 cites W2136435696 @default.
• W2991998463 cites W2138724655 @default.
• W2991998463 cites W2140606211 @default.
• W2991998463 cites W2150940141 @default.
• W2991998463 cites W2152531981 @default.
• W2991998463 cites W2158244090 @default.
• W2991998463 cites W2158807557 @default.
• W2991998463 cites W2159242554 @default.
• W2991998463 cites W2159812249 @default.
• W2991998463 cites W2160939822 @default.
• W2991998463 cites W2166148649 @default.
• W2991998463 cites W2166222330 @default.
• W2991998463 cites W2167659819 @default.
• W2991998463 cites W2170644672 @default.
• W2991998463 cites W2170873650 @default.
• W2991998463 cites W2176103393 @default.
• W2991998463 cites W2181841279 @default.
• W2991998463 cites W2190536949 @default.
• W2991998463 cites W2191660274 @default.
• W2991998463 cites W2212814050 @default.
• W2991998463 cites W2335728362 @default.
• W2991998463 cites W2399356043 @default.
• W2991998463 cites W2516947454 @default.
• W2991998463 cites W2519599559 @default.
• W2991998463 cites W2543481269 @default.
• W2991998463 cites W2599856014 @default.
• W2991998463 cites W2610958096 @default.
• W2991998463 cites W2735511385 @default.
• W2991998463 cites W2809181187 @default.
• W2991998463 cites W2907104950 @default.
• W2991998463 cites W2914427568 @default.
• W2991998463 cites W2946148932 @default.
• W2991998463 cites W2949763225 @default.
• W2991998463 cites W2951347155 @default.
• W2991998463 cites W2951936097 @default.
• W2991998463 cites W4249869172 @default.

• next