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• W2992051246 endingPage "106666" @default.
• W2992051246 startingPage "106666" @default.
• W2992051246 abstract "The transverse relaxation time (T2), measured with Carr-Purcell-Meiboom-Gill (CPMG) sequence, has been widely used to obtain the direct dimension data in two-dimension time domain NMR (2D TD-NMR). In this paper we are demonstrating that Continuous Wave Free Precession sequence, with low flip angle (CWFP-T1), can be an alternative to CPMG as direct detection dimension. CWFP-T1 is a fast single shot sequence, like CPMG, and yields an exponential signal governed predominantly by the longitudinal (T1) relaxation time. To obtain the correlations between T1 and T2 (T1-T2 maps) we are proposing the use of CPMG-CWFP-T1 pulse sequence. In this sequence CPMG encodes T2 information (indirect dimension) that modulates the CWFP-T1 (direct dimension) signal amplitudes. CPMG-CWFP-T1 experiments were compared with classical 2D sequences such as Saturation-Recovery-CPMG (SR-CPMG) and Inversion-Recovery-CPMG (IR-CPMG) sequence and yields similar results in phantom sample. The experimental time for the 2D sequences, using single scan, shows that SR-CPMG ≤ CPMG-CWFP-T1 < IR-CPMG. Experimental and simulated results demonstrated that 2D-CPMG-CWFP-T1 maps have higher resolution in T1 dimension than the techniques that uses CPMG as direct dimension. CPMG-CWFP-T1 sequence was also applied to study beef samples, and 2D maps showed higher resolution in the two fat signals than the classical IR-CPMG method." @default.
• W2992051246 created "2019-12-13" @default.
• W2992051246 creator A5015887252 @default.
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• W2992051246 date "2020-02-01" @default.
• W2992051246 modified "2023-10-13" @default.
• W2992051246 title "Using T1 as a direct detection dimension in two-dimensional time-domain NMR experiments using CWFP regime" @default.
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• W2992051246 doi "https://doi.org/10.1016/j.jmr.2019.106666" @default.
• W2992051246 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31846810" @default.
• W2992051246 hasPublicationYear "2020" @default.
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