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- W299207306 abstract "Chelerythrine (chloride) has previously been documented to be a potent and selective inhibitor of the serine/threonine-specific protein kinase C (PKC). In this study, it was shown that 10 microM chelerythrine completely inhibited serotonin secretion and partially inhibited phosphatidic acid formation in human blood platelets activated by thrombin (1U/ml). However, there was no effect on PKC activity as assessed by the level of phosphorylation of the 47K protein. Therefore, chelerythrine has been shown not to be a specific inhibitor of PKC. Without specifically affecting PKC activity, it is nevertheless capable of completely inhibiting platelet secretion, indicating that it may affect the signal transduction pathway responsible for platelet secretion at a point downstream or independent of PKC." @default.
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- W299207306 date "1996-06-01" @default.
- W299207306 modified "2023-09-23" @default.
- W299207306 title "Chelerythrine inhibits the secretory response of human blood platelets without specifically inhibiting protein kinase C." @default.
- W299207306 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9239807" @default.
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