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- W2992108140 abstract "To examine the hypothesis that collagen-stimulated platelets with associated factor XI can initiate intrinsic coagulation by an alternative pathway not requiring factor XII, platelets were washed using an improved method of albumin density gradient separation and assayed for coagulation factors. Factors II, VII, IX and X eluted readily, VIII and XII less readily; whereas V and XI remained associated. Collagen treatment produced a 2-fold increase in platelet-associated V and XI activities and activation of XI. Freezing and thawing platelets increased V activity 3-fold and XI activity 6-fold and these activities sedimented at 100,000 ×g. Platelet plasma membranes isolated by sucrose gradient centrifugation after glycerol lysis had PF3 activity, (per mg phospholipid) 5-fold greater than human brain phospholipid (Folch) and contained 0.45 units of V and 0.23 units XI per mg protein. Membranes had no detectable II, VII, VIII, IX, X and XII activities, progressively shortened clotting times when preincubated with XII-deficient plasma, and responded to collagen by enhancing XI activity. Platelets and platelet plasma membranes obtained from a patient with normal hemostasis and without apparant plasma XI had normal CICA and greater than normal XI. These observations support the view that XI is tightly bound to platelet membranes and can be activated by collagen in the absence of detectable XII with resultant initiation of intrinsic coagulation, even in the absence of plasma XI. (Supported by NIH Grant HL 14217 and AHA Grant 73–726.)" @default.
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- W2992108140 date "1975-01-01" @default.
- W2992108140 modified "2023-09-23" @default.
- W2992108140 title "Collagen-Induced Coagulant Activity (CICA) and Factor-V and -XI Activities of Platelets and Platelet Plasma Membranes" @default.
- W2992108140 doi "https://doi.org/10.1055/s-0039-1689582" @default.
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