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- W2992181519 abstract "Objective To investigate the effect of total flavone of gingko( TFG) against renal ischemia reperfusion injury ( IRI) in rats. Methods Totally 30 rats were randomly divided into five groups,with 6 rats in each: sham group, model group and TFG low,middle,high dose groups. TFG low,middle,high dose groups were given 50,100 and 200 mg/kg by intragastric administration ,once everyday for 3 days. Twelve hours after the last administration ,the IRI models were established in the model group and TFG groups through clamping bilateral renal arteries for 45 mins and then reperfusion for 24 hs. Serum creatinine ( SCr) and blood urea nitrogen ( BUN) were detected by chemical method; pathologic and ultrastructural changes were examined by optic and electron microscopy; the scores of renal tubule injure were estimated by paller method; renal cell apoptotic index ( AI) was examined by means of terminal deoxynucleotidyl transferase-mediated d-UTP nick end labeling. Results Compared with the sham group,the levels of SCr and BUN,the cell AI and the scores of renal tubule injure of the model group increased significantly ( P 0. 01) ; the aboved indexes of the TFG groups were significantly Lower than those of the model group ( P 0. 05 or 0. 01) ,and pathologic injure lightened. Conclusions TFG has significantly protective effect on renal IRI ,the mechanism maybe associated with suppressing apoptosis of tubular epithelial cells." @default.
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- W2992181519 date "2010-01-01" @default.
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- W2992181519 title "Protective effect and mechanism of total flavone of Gingko on renal ischemia reperfusion injury in rats." @default.
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