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- W2992297284 abstract "Hypoxia represents a frequent player in a number of malignancies, contributing to the development of the neoplastic disease. This review will discuss the means by which hypoxia powers the mechanisms behind cancer progression, with a majority of examples from lung cancer, the leading malignancy in terms of incidence and mortality rates (the frequent reference toward lung cancer is also for simplification purposes and follow up of the global mechanism in the context of a disease). The effects induced by low oxygen levels are orchestrated by hypoxia-inducible factors (HIFs) which regulate the expression of numerous genes involved in cancer progression. Hypoxia induces epithelial-to-mesenchymal transition (EMT) and metastasis through a complex machinery, by mediating various pathways such as TGF-β, PI3k/Akt, Wnt, and Jagged/Notch. Concomitantly, hypoxic environment has a vast implication in angiogenesis by stimulating vessel growth through the HIF-1α/VEGF axis. Low levels of oxygen can also promote the process through several other secondary factors, including ANGPT2, FGF, and HGF. Metabolic adaptations caused by hypoxia include the Warburg effect—a metabolic switch to glycolysis—and GLUT1 overexpression. The switch is achieved by directly increasing the expression of numerous glycolytic enzymes that are isoforms of those found in non-malignant cells." @default.
- W2992297284 created "2019-12-13" @default.
- W2992297284 creator A5011531047 @default.
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- W2992297284 creator A5064374408 @default.
- W2992297284 creator A5070120178 @default.
- W2992297284 creator A5086277139 @default.
- W2992297284 date "2019-12-05" @default.
- W2992297284 modified "2023-10-18" @default.
- W2992297284 title "Hypoxia: Overview on Hypoxia-Mediated Mechanisms with a Focus on the Role of HIF Genes" @default.
- W2992297284 cites W1489873347 @default.
- W2992297284 cites W1550989298 @default.
- W2992297284 cites W1565216318 @default.
- W2992297284 cites W1597158509 @default.
- W2992297284 cites W1689351220 @default.
- W2992297284 cites W1749022239 @default.
- W2992297284 cites W1869391303 @default.
- W2992297284 cites W1952952018 @default.
- W2992297284 cites W1964847767 @default.
- W2992297284 cites W1965313928 @default.
- W2992297284 cites W1968963363 @default.
- W2992297284 cites W1974040640 @default.
- W2992297284 cites W1974408946 @default.
- W2992297284 cites W1976880272 @default.
- W2992297284 cites W1976980661 @default.
- W2992297284 cites W1978139448 @default.
- W2992297284 cites W1979264220 @default.
- W2992297284 cites W1979323646 @default.
- W2992297284 cites W1982330633 @default.
- W2992297284 cites W1982861439 @default.
- W2992297284 cites W1986014993 @default.
- W2992297284 cites W1986873446 @default.
- W2992297284 cites W1989040551 @default.
- W2992297284 cites W1991477085 @default.
- W2992297284 cites W1993625584 @default.
- W2992297284 cites W1998664010 @default.
- W2992297284 cites W2001191004 @default.
- W2992297284 cites W2003602667 @default.
- W2992297284 cites W2007747524 @default.
- W2992297284 cites W2009410973 @default.
- W2992297284 cites W2010292117 @default.
- W2992297284 cites W2011810742 @default.
- W2992297284 cites W2016321140 @default.
- W2992297284 cites W2017574652 @default.
- W2992297284 cites W2022616393 @default.
- W2992297284 cites W2024131284 @default.
- W2992297284 cites W2025933554 @default.
- W2992297284 cites W2030739512 @default.
- W2992297284 cites W2031248825 @default.
- W2992297284 cites W2033958147 @default.
- W2992297284 cites W2035396934 @default.
- W2992297284 cites W2038230066 @default.
- W2992297284 cites W2041048564 @default.
- W2992297284 cites W2042773343 @default.
- W2992297284 cites W2043249221 @default.
- W2992297284 cites W2044257922 @default.
- W2992297284 cites W2044597300 @default.
- W2992297284 cites W2048013457 @default.
- W2992297284 cites W2057384910 @default.
- W2992297284 cites W2064689428 @default.
- W2992297284 cites W2066888615 @default.
- W2992297284 cites W2071822806 @default.
- W2992297284 cites W2072839085 @default.
- W2992297284 cites W2073262381 @default.
- W2992297284 cites W2073535977 @default.
- W2992297284 cites W2083268019 @default.
- W2992297284 cites W2085904846 @default.
- W2992297284 cites W2086595831 @default.
- W2992297284 cites W2087214360 @default.
- W2992297284 cites W2097713515 @default.
- W2992297284 cites W2103885904 @default.
- W2992297284 cites W2106831498 @default.
- W2992297284 cites W2113215822 @default.
- W2992297284 cites W2116715687 @default.
- W2992297284 cites W2116829237 @default.
- W2992297284 cites W2116974984 @default.
- W2992297284 cites W2124675440 @default.
- W2992297284 cites W2129992678 @default.
- W2992297284 cites W2130522035 @default.
- W2992297284 cites W2131436977 @default.
- W2992297284 cites W2133598334 @default.
- W2992297284 cites W2135347498 @default.
- W2992297284 cites W2136875815 @default.
- W2992297284 cites W2137371083 @default.
- W2992297284 cites W2139128338 @default.
- W2992297284 cites W2144954025 @default.
- W2992297284 cites W2145040878 @default.
- W2992297284 cites W2145972625 @default.
- W2992297284 cites W2146021659 @default.
- W2992297284 cites W2151762874 @default.
- W2992297284 cites W2152825998 @default.
- W2992297284 cites W2153784080 @default.
- W2992297284 cites W2163069245 @default.
- W2992297284 cites W2163252729 @default.
- W2992297284 cites W2164757740 @default.
- W2992297284 cites W2165235603 @default.
- W2992297284 cites W2204695292 @default.
- W2992297284 cites W2220340796 @default.