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- W2992307536 abstract "The posterodorsal medial amygdala (MePD) has a high concentration of receptors for gonadal hormones, is a sexually dimorphic region and dynamically controls the reproductive behavior of both males and females. Neurotrophic factors can promote dendritic spine remodeling and change synaptic input strength in a region-specific manner. Here, we analyzed the gene and protein expression of brain-derived neurotrophic factor (BDNF), insulin-like growth factor-I (IGF-1), polysialylated neural cell adhesion molecule (PSA-NCAM) and Ephrin-A4 in the MePD of adult males and females in diestrus, proestrus and estrus using real-time qPCR and fluorescent immunohistochemistry. The first approach showed their amplification except for Igf1 and the latter revealed that BDNF, IGF-1, PSA-NCAM and Ephrin-A4 are expressed in the MePD of the adult rats. Protein expression of these neurotrophic factors showed no differences between groups. However, proestrus females displayed a higher number of labelled puncta than males for BDNF expression and diestrus females for IGF-1 expression. In conjunction, results indicate that IGF-1 might be released rather than synthetized in the MePD, and the expression of specific neurotrophic factors varies specifically during proestrus. The dynamic modulation of BDNF and IGF-1 during this cyclic phase is coincident with synaptic changes and spine density remodeling in the MePD, the disinhibition of gonadotrophin secretion for ovulation and the display of sexual behavior." @default.
- W2992307536 created "2019-12-13" @default.
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- W2992307536 date "2020-02-01" @default.
- W2992307536 modified "2023-10-12" @default.
- W2992307536 title "Neurotrophic factors in the posterodorsal medial amygdala of male and cycling female rats" @default.
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- W2992307536 doi "https://doi.org/10.1016/j.brainresbull.2019.12.002" @default.
- W2992307536 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31812781" @default.
- W2992307536 hasPublicationYear "2020" @default.
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