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- W2992314257 abstract "Functional complementation of ataxia telangiectasia group D cells by microcell- mediated chromosome transfer of a single rearranged human chromosome and localization of the AT-D gene to the region 11q22.3-23.1. KA. Henning* (1). C . .L.Pmbert (2), A.A. Schultz (3). M. Smith (4). LD. McDaniel (3). T. Donlon (2). E.J. filaObridge (4). and E.C. Friedberg (1). (1) The University of Texas Southwestern Medical Center at Dallas. Dallas, Texas, USA, (2) Stanford University, Stanford, California, USA, (3) The University of Maryland, Baltimore, Maryland, USA, and (4) The University of California. Irvine, California, USA. Using the technique of microcell-mediated chromosome transfer we have identified a single nee-tagged human chromosome which corrects the phenotypes of increased gamma-ray sensitivity, and sensitivity to streptonigrin and bleomycin in AT-D cells. Additionally, AT-D cells carrying this chromosome are corrected for radio-resistant DNA synthesis and G2/M blockage after exposure to ionizing radiation. The complementing chromosome is a rearranged human chromosome 18 carrying translocated material from the long arm of chromosome 11. A normal chromosome 18 does not complement A T-D cells, however transfer of human chromosome 11 or 11 q does. DNA hybridization using single copy chromosome 11-specific probes reveals the presence of material from the region 11 q22.3-23.1 in the rearranged chromosome. Both the AT-A and the AT-C genes have been mapped close to this region, suggesting that there may be only a single wild-type AT gene or multiple closely-linked genes. Isolation and identification of this rearranged human chromosome containing a limited region of chromosome 11 offers a unique opportunity to define the genetic complexity of AT and to facilitate cloning of the A T-D gene by fUnctional complementation." @default.
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- W2992314257 date "1991-10-01" @default.
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- W2992314257 title "FUNCTIONAL COMPLEMENTATION OF ATAXIA TELANGIECTASIA GROUP-D CELLS BY MICROCELL-MEDIATED CHROMOSOME TRANSFER OF A SINGLE REARRANGED HUMAN-CHROMOSOME AND LOCALIZATION OF THE AT-D GENE TO THE REGION 11Q22.3-23.1" @default.
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