FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2992423789> ?p ?o ?g. }

• W2992423789 endingPage "250" @default.
• W2992423789 startingPage "239" @default.
• W2992423789 abstract "The male infertility of cattleyak resulted from spermatogenic arrest has greatly restricted the effective utilization of the heterosis from crossbreeding of cattle and yak. Based on our previous studies, the significant divergences of the transcriptomic and proteomic sequencing between yak and cattleyak prompt us to investigate the critical roles of microRNAs in post-transcriptional regulation of gene expression during spermatogenesis. TUNEL-POD analysis presented sharply decreased spermatogenic cell types and the increased apoptotic spermatogonia in cattleyak. The STA-PUT velocity sedimentation was employed to obtain spermatogonia and spermatocytes from cattle, yak and cattleyak and these spermatogenic cells were verified by the morphological and phenotypic identification. MicroRNA microarray showed that 27 differentially expressed miRNAs were simultaneously identified both in cattleyak vs cattle and in cattleyak vs yak comparisons. Further analysis revealed that the down-regulation of bta-let-7 families, bta-miR-125 and bta-miR-23a might impair the RA-induced differentiation of spermatogonia. Target gene analysis for differentially expressed miRNAs revealed that miRNAs targeted major players involved in vesicle-mediated transport, regulation of protein kinase activity and Pathways in cancer. In addition, spermatogonia transfection analysis revealed that the down-regulation of bta-miR-449a in the cattleyak might block the transition of male germ cells from the mitotic cycle to the meiotic program. The present study provided valuable information for future elucidating the regulatory roles of miRNAs involved in spermatogenic arrest of cattleyak." @default.
• W2992423789 created "2019-12-13" @default.
• W2992423789 creator A5006756147 @default.
• W2992423789 creator A5023502062 @default.
• W2992423789 creator A5026093004 @default.
• W2992423789 creator A5027852903 @default.
• W2992423789 creator A5034680102 @default.
• W2992423789 creator A5042586104 @default.
• W2992423789 creator A5042977952 @default.
• W2992423789 creator A5078617187 @default.
• W2992423789 creator A5083337554 @default.
• W2992423789 creator A5089116680 @default.
• W2992423789 date "2020-01-01" @default.
• W2992423789 modified "2023-10-16" @default.
• W2992423789 title "Bovid microRNAs involved in the process of spermatogonia differentiation into spermatocytes" @default.
• W2992423789 cites W142190260 @default.
• W2992423789 cites W144423133 @default.
• W2992423789 cites W1807437640 @default.
• W2992423789 cites W1843736399 @default.
• W2992423789 cites W1969670847 @default.
• W2992423789 cites W1977024213 @default.
• W2992423789 cites W1986317453 @default.
• W2992423789 cites W1990296722 @default.
• W2992423789 cites W1991065134 @default.
• W2992423789 cites W1995889915 @default.
• W2992423789 cites W2007043260 @default.
• W2992423789 cites W2009932279 @default.
• W2992423789 cites W2012319310 @default.
• W2992423789 cites W2022839356 @default.
• W2992423789 cites W2028994878 @default.
• W2992423789 cites W2032817531 @default.
• W2992423789 cites W2038774738 @default.
• W2992423789 cites W2044138586 @default.
• W2992423789 cites W2054011804 @default.
• W2992423789 cites W2059097898 @default.
• W2992423789 cites W2059645054 @default.
• W2992423789 cites W2067188495 @default.
• W2992423789 cites W2070053574 @default.
• W2992423789 cites W2071709406 @default.
• W2992423789 cites W2074257509 @default.
• W2992423789 cites W2082509810 @default.
• W2992423789 cites W2083977467 @default.
• W2992423789 cites W2090059904 @default.
• W2992423789 cites W2092158511 @default.
• W2992423789 cites W2097637842 @default.
• W2992423789 cites W2100499879 @default.
• W2992423789 cites W2117533395 @default.
• W2992423789 cites W2121148429 @default.
• W2992423789 cites W2122051251 @default.
• W2992423789 cites W2123527121 @default.
• W2992423789 cites W2137789399 @default.
• W2992423789 cites W2142349656 @default.
• W2992423789 cites W2147672884 @default.
• W2992423789 cites W2159835219 @default.
• W2992423789 cites W2165556478 @default.
• W2992423789 cites W2174044309 @default.
• W2992423789 cites W2237266875 @default.
• W2992423789 cites W2321525112 @default.
• W2992423789 cites W2333259830 @default.
• W2992423789 cites W2333541014 @default.
• W2992423789 cites W2344609745 @default.
• W2992423789 cites W2346495426 @default.
• W2992423789 cites W2462808437 @default.
• W2992423789 cites W2529642018 @default.
• W2992423789 cites W2610038606 @default.
• W2992423789 cites W2759429496 @default.
• W2992423789 cites W2783579130 @default.
• W2992423789 cites W2802249544 @default.
• W2992423789 doi "https://doi.org/10.7150/ijbs.38232" @default.
• W2992423789 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6949159" @default.
• W2992423789 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31929752" @default.
• W2992423789 hasPublicationYear "2020" @default.
• W2992423789 type Work @default.
• W2992423789 sameAs 2992423789 @default.
• W2992423789 citedByCount "21" @default.
• W2992423789 countsByYear W29924237892020 @default.
• W2992423789 countsByYear W29924237892021 @default.
• W2992423789 countsByYear W29924237892022 @default.
• W2992423789 countsByYear W29924237892023 @default.
• W2992423789 crossrefType "journal-article" @default.
• W2992423789 hasAuthorship W2992423789A5006756147 @default.
• W2992423789 hasAuthorship W2992423789A5023502062 @default.
• W2992423789 hasAuthorship W2992423789A5026093004 @default.
• W2992423789 hasAuthorship W2992423789A5027852903 @default.
• W2992423789 hasAuthorship W2992423789A5034680102 @default.
• W2992423789 hasAuthorship W2992423789A5042586104 @default.
• W2992423789 hasAuthorship W2992423789A5042977952 @default.
• W2992423789 hasAuthorship W2992423789A5078617187 @default.
• W2992423789 hasAuthorship W2992423789A5083337554 @default.
• W2992423789 hasAuthorship W2992423789A5089116680 @default.
• W2992423789 hasBestOaLocation W29924237891 @default.
• W2992423789 hasConcept C104317684 @default.
• W2992423789 hasConcept C123765429 @default.
• W2992423789 hasConcept C134018914 @default.
• W2992423789 hasConcept C145059251 @default.
• W2992423789 hasConcept C150194340 @default.
• W2992423789 hasConcept C153911025 @default.
• W2992423789 hasConcept C162317418 @default.

• next