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- W2992506706 abstract "Abstract Hepatocellular carcinoma (HCC) is the most prevalent type of malignant liver disease worldwide. Molecular changes in HCC collectively contribute to Wnt/β-catenin, as a tumor proliferative signaling pathway, toll-like receptors (TLRs), nuclear factor-kappa B (NF-κB), as well as the c-Jun NH2-terminal kinase (JNK), predominant signaling pathways linked to the release of tumor-promoting cytokines. It should also be noted that the Hippo signaling pathway plays an important role in organ size control, particularly in promoting tumorigenesis and HCC development. Nowadays, mesenchymal stromal cells (MSCs)-based therapies have been the subject of in vitro, in vivo, and clinical studies for liver such as cirrhosis, liver failure, and HCC. At present, despite the importance of basic molecular pathways of malignancies, limited information has been obtained on this background. Therefore, it can be difficult to determine the true concept of interactions between MSCs and tumor cells. What is known, these cells could migrate toward tumor sites so apply effects via paracrine interaction on HCC cells. For example, one of the inhibitory effects of MSCs is the overexpression of dickkopf-related protein 1 (DKK-1) as an important antagonist of the Wnt signaling pathway. A growing body of research challenging the therapeutic roles of MSCs through the secretion of various trophic factors in HCC. This review illustrates the complex behavior of MSCs and precisely how their inhibitory signals interface with HCC tumor cells." @default.
- W2992506706 created "2019-12-13" @default.
- W2992506706 creator A5042572667 @default.
- W2992506706 creator A5042763558 @default.
- W2992506706 creator A5044453202 @default.
- W2992506706 creator A5054124274 @default.
- W2992506706 creator A5078501908 @default.
- W2992506706 creator A5081259703 @default.
- W2992506706 date "2019-12-01" @default.
- W2992506706 modified "2023-10-16" @default.
- W2992506706 title "Mesenchymal stromal cells induce inhibitory effects on hepatocellular carcinoma through various signaling pathways" @default.
- W2992506706 cites W1594860261 @default.
- W2992506706 cites W1880575899 @default.
- W2992506706 cites W1934417607 @default.
- W2992506706 cites W1965592851 @default.
- W2992506706 cites W1972128179 @default.
- W2992506706 cites W1973027060 @default.
- W2992506706 cites W1973354681 @default.
- W2992506706 cites W1974551062 @default.
- W2992506706 cites W1976392251 @default.
- W2992506706 cites W1979837801 @default.
- W2992506706 cites W1980506310 @default.
- W2992506706 cites W1986413639 @default.
- W2992506706 cites W1987633286 @default.
- W2992506706 cites W1990172019 @default.
- W2992506706 cites W1991623155 @default.
- W2992506706 cites W1992185305 @default.
- W2992506706 cites W1992677374 @default.
- W2992506706 cites W1992841021 @default.
- W2992506706 cites W1994219871 @default.
- W2992506706 cites W1995938892 @default.
- W2992506706 cites W1998915515 @default.
- W2992506706 cites W1999355130 @default.
- W2992506706 cites W2000229809 @default.
- W2992506706 cites W2000307707 @default.
- W2992506706 cites W2001747259 @default.
- W2992506706 cites W2006626994 @default.
- W2992506706 cites W2010893399 @default.
- W2992506706 cites W2011045750 @default.
- W2992506706 cites W2013485183 @default.
- W2992506706 cites W2017476014 @default.
- W2992506706 cites W2017969565 @default.
- W2992506706 cites W2018206475 @default.
- W2992506706 cites W2019712119 @default.
- W2992506706 cites W2028937813 @default.
- W2992506706 cites W2039254172 @default.
- W2992506706 cites W2039582913 @default.
- W2992506706 cites W2040002581 @default.
- W2992506706 cites W2045151900 @default.
- W2992506706 cites W2046056065 @default.
- W2992506706 cites W2047142573 @default.
- W2992506706 cites W2049487321 @default.
- W2992506706 cites W2051935450 @default.
- W2992506706 cites W2053275321 @default.
- W2992506706 cites W2057211093 @default.
- W2992506706 cites W2058855830 @default.
- W2992506706 cites W2059748163 @default.
- W2992506706 cites W2060795488 @default.
- W2992506706 cites W2064014317 @default.
- W2992506706 cites W2064364170 @default.
- W2992506706 cites W2064735925 @default.
- W2992506706 cites W2065902307 @default.
- W2992506706 cites W2067662036 @default.
- W2992506706 cites W2068132526 @default.
- W2992506706 cites W2068290020 @default.
- W2992506706 cites W2070179539 @default.
- W2992506706 cites W2073024911 @default.
- W2992506706 cites W2073343697 @default.
- W2992506706 cites W2074688366 @default.
- W2992506706 cites W2076704745 @default.
- W2992506706 cites W2076744652 @default.
- W2992506706 cites W2078369117 @default.
- W2992506706 cites W2083808914 @default.
- W2992506706 cites W2093677236 @default.
- W2992506706 cites W2099584305 @default.
- W2992506706 cites W2099709490 @default.
- W2992506706 cites W2100013146 @default.
- W2992506706 cites W2102930587 @default.
- W2992506706 cites W2104774845 @default.
- W2992506706 cites W2112699535 @default.
- W2992506706 cites W2115583388 @default.
- W2992506706 cites W2116775917 @default.
- W2992506706 cites W2118278569 @default.
- W2992506706 cites W2121249810 @default.
- W2992506706 cites W2121722272 @default.
- W2992506706 cites W2123067662 @default.
- W2992506706 cites W2124791313 @default.
- W2992506706 cites W2126956863 @default.
- W2992506706 cites W2127092375 @default.
- W2992506706 cites W2132256680 @default.
- W2992506706 cites W2132692852 @default.
- W2992506706 cites W2135726634 @default.
- W2992506706 cites W2138860727 @default.
- W2992506706 cites W2139737762 @default.
- W2992506706 cites W2141369960 @default.
- W2992506706 cites W2141577754 @default.
- W2992506706 cites W2142384246 @default.
- W2992506706 cites W2143022774 @default.
- W2992506706 cites W2143192323 @default.
- W2992506706 cites W2144477082 @default.