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• W2992540886 abstract "Abstract The objective of this experiment was to examine potential differential methylation of DNA as a mechanism for altered behavioral and stress responses in prenatally stressed (PNS) compared with nonprenatally stressed (Control) young bull calves. Mature Brahman cows (n = 48) were transported for 2-h periods at 60 ± 5, 80 ± 5, 100 ± 5, 120 ± 5, and 140 ± 5 d of gestation (Transported group) or maintained as nontransported Controls (n = 48). From the offspring born to Transported and Control cows, a subset of 28-d-old intact bulls (n = 7 PNS; n = 7 Control) were evaluated for methylation of DNA of behavior and stress response–associated genes. Methylation of DNA from white blood cells was assessed via reduced representation bisulfite sequencing methods. Because increased methylation of DNA within gene promoter regions has been associated with decreased transcriptional activity of the corresponding gene, differentially methylated (P ≤ 0.05) CG sites (cytosine followed by a guanine nucleotide) located within promoter regions (n = 1,205) were used to predict (using Ingenuity Pathway Analysis software) alterations to canonical pathways in PNS compared with Control bull calves. Among differentially methylated genes (P ≤ 0.05) related to behavior and the stress response were OPRK1, OPRM1, PENK, POMC, NR3C2, TH, DRD1, DRD5, COMT, HTR6, HTR5A, GABRA4, GABRQ, and GAD2. Among altered (P &lt; 0.05) signaling pathways related to behavior and the stress response were Opioid Signaling, Corticotropin-Releasing Hormone Signaling, Dopamine Receptor Signaling, Dopamine-DARPP32 Feedback in cAMP Signaling, Serotonin Receptor Signaling, and GABA Receptor Signaling. Alterations to behavior and stress response–related genes and canonical pathways supported previously observed elevations in temperament score and serum cortisol through weaning in the larger population of PNS calves from which bulls in this study were derived. Differential methylation of DNA and predicted alterations to behavior and stress response–related pathways in PNS compared with Control bull calves suggest epigenetic programming of behavior and the stress response in utero." @default.
• W2992540886 created "2019-12-13" @default.
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• W2992540886 date "2019-12-06" @default.
• W2992540886 modified "2023-10-13" @default.
• W2992540886 title "Influence of prenatal transportation stress-induced differential DNA methylation on the physiological control of behavior and stress response in suckling Brahman bull calves" @default.
• W2992540886 cites W1200631952 @default.
• W2992540886 cites W1523695827 @default.
• W2992540886 cites W1528274454 @default.
• W2992540886 cites W1586199023 @default.
• W2992540886 cites W1604113621 @default.
• W2992540886 cites W1846578820 @default.
• W2992540886 cites W1966377499 @default.
• W2992540886 cites W1966842227 @default.
• W2992540886 cites W1971854206 @default.
• W2992540886 cites W1973867244 @default.
• W2992540886 cites W1978657121 @default.
• W2992540886 cites W1979031324 @default.
• W2992540886 cites W1980761809 @default.
• W2992540886 cites W1981416028 @default.
• W2992540886 cites W1981496403 @default.
• W2992540886 cites W1982902601 @default.
• W2992540886 cites W1983922562 @default.
• W2992540886 cites W1984004239 @default.
• W2992540886 cites W1984486655 @default.
• W2992540886 cites W1990518668 @default.
• W2992540886 cites W1990958459 @default.
• W2992540886 cites W1992364990 @default.
• W2992540886 cites W1998073743 @default.
• W2992540886 cites W1998517881 @default.
• W2992540886 cites W2000547596 @default.
• W2992540886 cites W2001405592 @default.
• W2992540886 cites W2002064850 @default.
• W2992540886 cites W2004787375 @default.
• W2992540886 cites W2006215870 @default.
• W2992540886 cites W2008623200 @default.
• W2992540886 cites W2012558225 @default.
• W2992540886 cites W2020469940 @default.
• W2992540886 cites W2023496972 @default.
• W2992540886 cites W2024455218 @default.
• W2992540886 cites W2025108780 @default.
• W2992540886 cites W2032729792 @default.
• W2992540886 cites W2033063377 @default.
• W2992540886 cites W2035152097 @default.
• W2992540886 cites W2036234489 @default.
• W2992540886 cites W2036455062 @default.
• W2992540886 cites W2038652891 @default.
• W2992540886 cites W2039055473 @default.
• W2992540886 cites W2043184629 @default.
• W2992540886 cites W2043549263 @default.
• W2992540886 cites W2049539653 @default.
• W2992540886 cites W2049545055 @default.
• W2992540886 cites W2051661210 @default.
• W2992540886 cites W2052759804 @default.
• W2992540886 cites W2060890501 @default.
• W2992540886 cites W206125387 @default.
• W2992540886 cites W2064345987 @default.
• W2992540886 cites W2067481123 @default.
• W2992540886 cites W2071154937 @default.
• W2992540886 cites W2072228597 @default.
• W2992540886 cites W2076942602 @default.
• W2992540886 cites W2078132872 @default.
• W2992540886 cites W2080709600 @default.
• W2992540886 cites W2080942607 @default.
• W2992540886 cites W2082423551 @default.
• W2992540886 cites W2085879736 @default.
• W2992540886 cites W2086880198 @default.
• W2992540886 cites W2091602444 @default.
• W2992540886 cites W2092363037 @default.
• W2992540886 cites W2094850376 @default.
• W2992540886 cites W2100731734 @default.
• W2992540886 cites W2101551147 @default.
• W2992540886 cites W2104146295 @default.
• W2992540886 cites W2108978450 @default.
• W2992540886 cites W2110558389 @default.
• W2992540886 cites W2110743747 @default.
• W2992540886 cites W2117347068 @default.
• W2992540886 cites W2117964342 @default.
• W2992540886 cites W2125631026 @default.
• W2992540886 cites W2126847571 @default.
• W2992540886 cites W2140683271 @default.
• W2992540886 cites W2141124547 @default.
• W2992540886 cites W2142525943 @default.
• W2992540886 cites W2147381727 @default.
• W2992540886 cites W2156399923 @default.
• W2992540886 cites W2158294015 @default.
• W2992540886 cites W2159083927 @default.
• W2992540886 cites W2159530849 @default.
• W2992540886 cites W2169594398 @default.
• W2992540886 cites W2170485939 @default.
• W2992540886 cites W2171512984 @default.

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