FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2992574296> ?p ?o ?g. }

• W2992574296 abstract "Abstract Patients with Gaucher disease exhibit substantial evidence of impairment of their immune system, namely, increased serum levels of proinflammatory cytokines and immunoglobulins, and increased incidence of B-cell malignancies, such as non-Hodgkin’s lymphoma, MGUS and multiple myeloma. We investigated peripheral blood T-lymphocyte subpopulations with dual color flow cytometry, as well as the direction of T-lymphocyte activation, by using intracytoplasmic immunostaining for IL-2, IL-4, IL-10 and IFN-gamma, on resting CD4+ and CD8+ T-lymphocytes and following activation with PMA- 1 with the presence of Brefeldin-A. Evaluations were performed on 16 patients with type I Gaucher disease and on 17 healthy controls. Patients had significantly decreased absolute lymphocyte count (1621±684 vs 2148±566/mm3, p=0.013), CD3+ (1197±478 vs 1508±431/mm3, p=0.045) and CD4+ T-lymphocytes (658±245 vs 945±253/mm3, p=0.021), but not CD8+ T-lymphocytes (491±331 vs 486±189/mm3, p: n.s.), resulting in a significant reduction of the CD4/CD8 ratio (1.59±0.68 vs 2.16±0.83, p=0.041). The populations of naive CD4+CD45RA+ and of memory CD4+CD45RO+ T-lymphocytes were also significantly decreased (218±128 vs 432±179/mm3, p=0.0005 and 484±185 vs 631±231/mm3, p=0.056 respectively), however, CD8+CD45RA+ and CD8+CD45RO+ subpopulations did nor differ significantly, when compared to controls. CD3−CD56+, but not CD3+CD56+ lymphocytes were also decreased (131±82 vs 199±97/mm3, p=0.037). Patients had higher percentages of CD8+ (29.2±9.7 vs 23.5±6.8%, p=0.042), CD8+CD45RA+ (22.1±6.2 vs 18.3±5.0%, p=0.046) and CD8+CD45RO+ T-lymphocytes (13.2±6.2 vs 9.6±3.7%, p=0.027), as well as of activated CD8+HLA-DR+ (0.93±0.68 vs 0.48±0.21%, p=0.008) and CD4+HLA-DR+ T-lymphocytes (1.77±0.93 vs 1.09±0.48%, p=0.008). Moreover, although both, the absolute number and the percentage of CD20+ B-lymphocytes were similar, patients exhibited significantly increased absolute number and percentage of CD5+CD20+ B-lymphocytes (1.63±0.55 vs 0.64±0.37% p=0.00002 and 29±20 vs 13±8/mm3, p=0.011, respectively). Finally, patients with Gaucher disease had significantly increased resting TH2-polarized CD4+T-lymphocytes (CD4+IL-10+: 0.41±0.29 vs 0.24±0.11%, p=0.045) and TH1-polarized CD8+ T-lymphocytes (CD8+IFNγ+: 0.15±0.07 vs 0.08±0.04%, p=0.005, CD8+IL10+: 0.22±0.08 vs 0.32±0.014, p=0.052, and IFNγ+/IL4+ ratio among the CD8+ population 2.54±2.1 vs 1.08±0.91, p=0.018). Following mitogenic activation a very significant impairment of obtaining the TH1 phenotype was observed (CD4+IL2+ lymphocytes 33.7±17.1 vs 65.4±6.1%, p&lt;0.00001). The above findings suggest that in patients with Gaucher disease there is a significant numerical impairment of T-helper lymphocytes and a shift towards TH-2 direction of lymphocyte activation. These findings may explain the rarity of autoimmune manifestations despite the chronic inflammatory reaction, as well as the increased incidence of lymphoid malignancies, which has been reported among patients suffering from this disease." @default.
• W2992574296 created "2019-12-13" @default.
• W2992574296 creator A5029901306 @default.
• W2992574296 creator A5032102775 @default.
• W2992574296 creator A5041806045 @default.
• W2992574296 creator A5048477374 @default.
• W2992574296 creator A5052611698 @default.
• W2992574296 creator A5067658277 @default.
• W2992574296 creator A5075894087 @default.
• W2992574296 creator A5088869439 @default.
• W2992574296 date "2008-11-16" @default.
• W2992574296 modified "2023-09-29" @default.
• W2992574296 title "Impaired T-Lymphocyte Subpopulations and Deranged Profile of Immunologic Activation in Patients with Gaucher Disease Type I" @default.
• W2992574296 doi "https://doi.org/10.1182/blood.v112.11.4915.4915" @default.
• W2992574296 hasPublicationYear "2008" @default.
• W2992574296 type Work @default.
• W2992574296 sameAs 2992574296 @default.
• W2992574296 citedByCount "0" @default.
• W2992574296 crossrefType "journal-article" @default.
• W2992574296 hasAuthorship W2992574296A5029901306 @default.
• W2992574296 hasAuthorship W2992574296A5032102775 @default.
• W2992574296 hasAuthorship W2992574296A5041806045 @default.
• W2992574296 hasAuthorship W2992574296A5048477374 @default.
• W2992574296 hasAuthorship W2992574296A5052611698 @default.
• W2992574296 hasAuthorship W2992574296A5067658277 @default.
• W2992574296 hasAuthorship W2992574296A5075894087 @default.
• W2992574296 hasAuthorship W2992574296A5088869439 @default.
• W2992574296 hasConcept C114684123 @default.
• W2992574296 hasConcept C126322002 @default.
• W2992574296 hasConcept C134018914 @default.
• W2992574296 hasConcept C167672396 @default.
• W2992574296 hasConcept C203014093 @default.
• W2992574296 hasConcept C2777761686 @default.
• W2992574296 hasConcept C2992881475 @default.
• W2992574296 hasConcept C71924100 @default.
• W2992574296 hasConcept C8891405 @default.
• W2992574296 hasConceptScore W2992574296C114684123 @default.
• W2992574296 hasConceptScore W2992574296C126322002 @default.
• W2992574296 hasConceptScore W2992574296C134018914 @default.
• W2992574296 hasConceptScore W2992574296C167672396 @default.
• W2992574296 hasConceptScore W2992574296C203014093 @default.
• W2992574296 hasConceptScore W2992574296C2777761686 @default.
• W2992574296 hasConceptScore W2992574296C2992881475 @default.
• W2992574296 hasConceptScore W2992574296C71924100 @default.
• W2992574296 hasConceptScore W2992574296C8891405 @default.
• W2992574296 hasLocation W29925742961 @default.
• W2992574296 hasOpenAccess W2992574296 @default.
• W2992574296 hasPrimaryLocation W29925742961 @default.
• W2992574296 hasRelatedWork W1975766280 @default.
• W2992574296 hasRelatedWork W2023994866 @default.
• W2992574296 hasRelatedWork W2054894950 @default.
• W2992574296 hasRelatedWork W2358889835 @default.
• W2992574296 hasRelatedWork W2359144929 @default.
• W2992574296 hasRelatedWork W2360857324 @default.
• W2992574296 hasRelatedWork W2362804668 @default.
• W2992574296 hasRelatedWork W2364708402 @default.
• W2992574296 hasRelatedWork W2370978820 @default.
• W2992574296 hasRelatedWork W2371815043 @default.
• W2992574296 hasRelatedWork W2373125339 @default.
• W2992574296 hasRelatedWork W2380756249 @default.
• W2992574296 hasRelatedWork W2380886562 @default.
• W2992574296 hasRelatedWork W2383319079 @default.
• W2992574296 hasRelatedWork W2391226973 @default.
• W2992574296 hasRelatedWork W2392838159 @default.
• W2992574296 hasRelatedWork W3024783649 @default.
• W2992574296 hasRelatedWork W3030647700 @default.
• W2992574296 hasRelatedWork W3030722814 @default.
• W2992574296 hasRelatedWork W3149047701 @default.
• W2992574296 isParatext "false" @default.
• W2992574296 isRetracted "false" @default.
• W2992574296 magId "2992574296" @default.
• W2992574296 workType "article" @default.