FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2992600587> ?p ?o ?g. }

• W2992600587 endingPage "5878" @default.
• W2992600587 startingPage "5869" @default.
• W2992600587 abstract "Long noncoding RNA (LncRNA) functions as multiple mechanisms, including DNA methylation in colorectal cancer (CRC). ADAMTS12 was applied as biomarkers in CRC via abnormally DNA methylation. Lnc-AK001058 gene, which was reported dysregulated in CRC, is located adjacent to the gene ADAMTS12. However, little is known about the role of AK001058 during the proliferation and migration of CRC.In present study, quantitative RT-PCR were used to measure AK001058 and ADAMTS12 expression levels, and western blotting assays were performed to measure ADAMTS12 expression in CRC cells. Methylation-specific PCR (MSP) was applied to measure the methylation of the CpG islands of the ADAMTS12 promoter. Cell proliferation, migration, invasion and cycle assays ware utilized to analyze the role of AK001058 in CRC.The results indicated that the expression of AK001058 was significantly increased in CRC. Overexpression of AK001058 could suppress the expression of ADAMTS12. AK001058 also significantly promoted cell proliferation, migration and invasion, and prolonged S stage of CRC, while silencing the expression of AK001058 showed contrary effects. Moreover, compared with negative control and AK001058-NC groups, overexpression of AK001058 could increase the DNA methylation level of ADAMTS12 gene promoter in CRC, while si-AK001058 could reverse this effect.In conclusion, AK001058 promotes the proliferation, invasion, migration, and prolonged S stage of CRC by regulating methylation of ADAMTS12. Our research will provide new insights for the biomarker of colorectal cancer diagnose and new clues for clinical treatment." @default.
• W2992600587 created "2019-12-13" @default.
• W2992600587 creator A5008849547 @default.
• W2992600587 creator A5029153524 @default.
• W2992600587 creator A5042580362 @default.
• W2992600587 creator A5050244262 @default.
• W2992600587 creator A5063519121 @default.
• W2992600587 creator A5074140059 @default.
• W2992600587 date "2019-01-01" @default.
• W2992600587 modified "2023-09-27" @default.
• W2992600587 title "AK001058 promotes the proliferation and migration of colorectal cancer cells by regulating methylation of ADAMTS12." @default.
• W2992600587 cites W1639623904 @default.
• W2992600587 cites W1972247867 @default.
• W2992600587 cites W1977105608 @default.
• W2992600587 cites W1984605873 @default.
• W2992600587 cites W1988366520 @default.
• W2992600587 cites W1990711772 @default.
• W2992600587 cites W2001527227 @default.
• W2992600587 cites W2002444335 @default.
• W2992600587 cites W2003571176 @default.
• W2992600587 cites W2008352261 @default.
• W2992600587 cites W2018115135 @default.
• W2992600587 cites W2034269086 @default.
• W2992600587 cites W2054537489 @default.
• W2992600587 cites W2059878940 @default.
• W2992600587 cites W2074465151 @default.
• W2992600587 cites W2085344264 @default.
• W2992600587 cites W2089943125 @default.
• W2992600587 cites W2091161969 @default.
• W2992600587 cites W2097606112 @default.
• W2992600587 cites W2106090241 @default.
• W2992600587 cites W2107821075 @default.
• W2992600587 cites W2108532050 @default.
• W2992600587 cites W2131474316 @default.
• W2992600587 cites W2141831115 @default.
• W2992600587 cites W2161817637 @default.
• W2992600587 cites W2162977739 @default.
• W2992600587 cites W2417456911 @default.
• W2992600587 cites W2591199714 @default.
• W2992600587 cites W2888956514 @default.
• W2992600587 cites W2892262064 @default.
• W2992600587 cites W2900865173 @default.
• W2992600587 cites W2997865763 @default.
• W2992600587 cites W4233176852 @default.
• W2992600587 cites W4251060590 @default.
• W2992600587 cites W635191475 @default.
• W2992600587 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6789239" @default.
• W2992600587 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31632555" @default.
• W2992600587 hasPublicationYear "2019" @default.
• W2992600587 type Work @default.
• W2992600587 sameAs 2992600587 @default.
• W2992600587 citedByCount "6" @default.
• W2992600587 countsByYear W29926005872020 @default.
• W2992600587 countsByYear W29926005872021 @default.
• W2992600587 countsByYear W29926005872022 @default.
• W2992600587 crossrefType "journal-article" @default.
• W2992600587 hasAuthorship W2992600587A5008849547 @default.
• W2992600587 hasAuthorship W2992600587A5029153524 @default.
• W2992600587 hasAuthorship W2992600587A5042580362 @default.
• W2992600587 hasAuthorship W2992600587A5050244262 @default.
• W2992600587 hasAuthorship W2992600587A5063519121 @default.
• W2992600587 hasAuthorship W2992600587A5074140059 @default.
• W2992600587 hasConcept C104317684 @default.
• W2992600587 hasConcept C119056186 @default.
• W2992600587 hasConcept C140173407 @default.
• W2992600587 hasConcept C150194340 @default.
• W2992600587 hasConcept C153911025 @default.
• W2992600587 hasConcept C190727270 @default.
• W2992600587 hasConcept C33288867 @default.
• W2992600587 hasConcept C54355233 @default.
• W2992600587 hasConcept C86803240 @default.
• W2992600587 hasConceptScore W2992600587C104317684 @default.
• W2992600587 hasConceptScore W2992600587C119056186 @default.
• W2992600587 hasConceptScore W2992600587C140173407 @default.
• W2992600587 hasConceptScore W2992600587C150194340 @default.
• W2992600587 hasConceptScore W2992600587C153911025 @default.
• W2992600587 hasConceptScore W2992600587C190727270 @default.
• W2992600587 hasConceptScore W2992600587C33288867 @default.
• W2992600587 hasConceptScore W2992600587C54355233 @default.
• W2992600587 hasConceptScore W2992600587C86803240 @default.
• W2992600587 hasIssue "9" @default.
• W2992600587 hasLocation W29926005871 @default.
• W2992600587 hasOpenAccess W2992600587 @default.
• W2992600587 hasPrimaryLocation W29926005871 @default.
• W2992600587 hasRelatedWork W1542500687 @default.
• W2992600587 hasRelatedWork W2067963606 @default.
• W2992600587 hasRelatedWork W2081243758 @default.
• W2992600587 hasRelatedWork W2084654188 @default.
• W2992600587 hasRelatedWork W2090032248 @default.
• W2992600587 hasRelatedWork W2319463263 @default.
• W2992600587 hasRelatedWork W2417345120 @default.
• W2992600587 hasRelatedWork W2417387999 @default.
• W2992600587 hasRelatedWork W2612908078 @default.
• W2992600587 hasRelatedWork W2990718411 @default.
• W2992600587 hasVolume "11" @default.
• W2992600587 isParatext "false" @default.
• W2992600587 isRetracted "false" @default.
• W2992600587 magId "2992600587" @default.

• next