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- W2992622367 abstract "Chemotherapeutic agents are in wide use for malignancies despite their negative side effects. This study is a quest for a different source of anticancer drug especially from microbial sources. A total of ten Actinomycete strains were obtained from the soil samples to test the L-asparaginase activity. Three of them proved to be potent producers of the enzyme with higher amounts of enzyme upto 63 IU/ml. The strain was sequenced for the gene sequences of 16srRNA and L-asparaginase and was compared with the available data at NCBI. The molecular weight of the enzyme produced by the assay was determined to be 138 kDa. The three dimensional structure of the Lasparaginase enzyme was determined. The crude enzyme sample was treated as anticancer drug for invivo therapy of tumor induced mice. Promising results were obtained from the experiments as the drug increased the life span of the animals when compared to the test controls. The significant changes towards the normal by L-Asparaginase crude extract treatment indicate a protective effect on organ functions. Key words: L-asparaginase, actinomycetes, hematology, invivo study" @default.
- W2992622367 created "2019-12-13" @default.
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- W2992622367 date "2017-03-23" @default.
- W2992622367 modified "2023-09-26" @default.
- W2992622367 title "Anticancer enzymes from actinomycetes enhance therapy of tumor induced mice" @default.
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