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• W2992655502 abstract "Vertical transmission of HIV from mother to child accounts for many of the new cases seen worldwide. There is currently no vaccine to mitigate this transmission, and there has been limited research on the effects that lentiviral infection has on the innate immune system in oral tissues of infected children. To fill this knowledge gap, our laboratory studied infant rhesus macaques to evaluate how acute SIV/SHIV infections impacted ILC3 and NK cells, which are immune cells critical for mucosal homeostasis and antimicrobial defense. Our data revealed that SIV/SHIV infection led to a depletion of ILC3 and an increase of NK cells and to a functional shift from a homeostatic to a multifunctional proinflammatory state. Taking the results together, we describe how lentiviral infection perturbs the oral and gastrointestinal mucosae of infant macaques through alterations of resident innate immune cells giving rise to chronic inflammation and potentially exacerbating morbidity and mortality in children living with HIV." @default.
• W2992655502 created "2019-12-13" @default.
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• W2992655502 date "2020-02-14" @default.
• W2992655502 modified "2023-10-01" @default.
• W2992655502 title "Functional Perturbation of Mucosal Group 3 Innate Lymphoid and Natural Killer Cells in Simian-Human Immunodeficiency Virus/Simian Immunodeficiency Virus-Infected Infant Rhesus Macaques" @default.
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• W2992655502 doi "https://doi.org/10.1128/jvi.01644-19" @default.
• W2992655502 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7022363" @default.
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• W2992655502 hasPublicationYear "2020" @default.
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