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• W2992707453 abstract "Nickel oxide loaded on zirconia (NiO/ZrO2) as an expedient catalyst is reported for the synthesis of 18 unsymmetrical 1,4-dihydropyridine derivatives. The Lewis acidic nature of the catalyst proved an excellent choice for the one-pot, four-component fusion reaction with excellent yields of 89-98% and a completion time of 20-45 min. Mechanistic studies show that enamine and imine functionalities are the two possible pathways for the formation of 1,4-dihydropyridines with high selectivity. Crystal structures of two novel compounds (5a, 5c) were reported. The catalyst demonstrated reusability up to six cycles. The reaction at room temperature and ethanol as a solvent make this protocol green and economical." @default.
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• W2992707453 date "2019-12-05" @default.
• W2992707453 modified "2023-10-15" @default.
• W2992707453 title "Four-Component Fusion Protocol with NiO/ZrO₂ as a Robust Recyclable Catalyst for Novel 1,4-Dihydropyridines" @default.
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• W2992707453 doi "https://doi.org/10.1021/acsomega.9b02608" @default.
• W2992707453 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6921676" @default.
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