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- W2992736072 abstract "Purpose: The purpose of this study was to investigate the possible effects of chronic ethanol intake on theendocrine pancreas of rats.Material and Metods: The study was performed on 17 male Wistar albino rats. The laboratory animals dividedinto two groups as experiment and control. The experimental group was fed with a modified liquid diet (MLD)containing 7.2 % of ethanol during six months. Control rats were fed by isocaloric MLD without ethanol. At theend of the experiment rats were sacrified by cervical dislocation and their pancreas tissue were excised. Afterroutine tissue process, pancreas were embedded in paraffin. 6 μ section were stained with H-E, Crossman'stricrome, toluidin blue, Grimelius and aldehyde fuchsin methods and examined by light microscope.Results: When compared with control group ethanol group showed ducts and widened capillaries in islets ofLangerhans. Vacuolization were detected in islets of Langerhans in both intracellular and extracellular zones.Alpha cells presented ring like distribution at the periphery of islets of Langerhans in both examined groups ofrats, but ethanol groups showed increased density of granules. In contrast in ethanol group, Beta cells werelocalized in the center of the islets and showed decreased density of granules.Conclusion: We concluded that ethanol has structural damaging effects both directly and indirectly on endocrinepancreas directly or indirectly.Key Words: Alcohol, Langerhans Islets, Rat, Microscope." @default.
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- W2992736072 date "2002-01-01" @default.
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- W2992736072 title "The Histologic Effects of Alcohol on Endocrine Pancreas" @default.
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