FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2992783192> ?p ?o ?g. }

• W2992783192 abstract "Abstract Background An extremely rare condition, radiation-induced angiosarcoma is characterized by a poor prognosis, high recurrence rate and lack of effective treatment. Herein, we present a case report of a 48-year-old female patient with radiation-induced abdominal wall angiosarcoma who showed a dramatic response to low-dose apatinib. Case presentation The patient, who was diagnosed with cervical squamous cell carcinoma 20 years ago, had received radiotherapy and chemotherapy after operation. Angiosarcomas of the abdominal wall appeared 9 years later. After repeated surgical operations and intravenous chemotherapy for the angiosarcomas, the patient developed tumor recurrence and pulmonary metastasis. The abdominal wall tumors showed repeated rupture and bleeding, with poor wound healing. On evaluation, laboratory findings detected the negative serum tumor markers CEA, CA 125, CA 15–3 and CA 19–9. Imaging showed multiple subcutaneous nodules and masses in the abdominal wall, accompanied by suspected small subpleural nodule at the lower lobe of the right lung. Immunohistochemistry of previous surgical pathology indicated that CD31, ERG and Vim were positive. The result of whole exome sequencing suggested the mutations of BRAF and HRAS, and the amplification of MYC. Based on the above results, the patient was clinically diagnosed with radiation-induced angiosarcoma of the abdominal wall with pulmonary metastasis. The patient was treated with low-dose apatinib and rejected reoperation or chemotherapy. Results At the 6-month follow-up visit, the abdominal wall lesions that had previously ruptured stopped bleeding and showed significant shrinkage. Imaging showed that most of the abdominal wall lesions had partially regressed, and some of the lesions on the abdominal wall and the suspected lesion of subpleural nodule at the lower lobe of the right lung had disappeared. Conclusions We described this case and reviewed the literature on radiation-related angiosarcoma. Importantly, this case suggests that apatinib may be an effective and sensitive treatment for radiation-induced angiosarcoma even at the lowest dosage, without aggravating the bleeding of lesions." @default.
• W2992783192 created "2019-12-13" @default.
• W2992783192 creator A5003046062 @default.
• W2992783192 creator A5012626231 @default.
• W2992783192 creator A5025018891 @default.
• W2992783192 creator A5032071728 @default.
• W2992783192 creator A5040388481 @default.
• W2992783192 date "2019-12-01" @default.
• W2992783192 modified "2023-10-17" @default.
• W2992783192 title "Treatment of consistent BRAF/HRAS gene mutation and MYC amplification radiation-induced abdominal wall angiosarcoma with low-dose apatinib: a case report" @default.
• W2992783192 cites W1515613813 @default.
• W2992783192 cites W1816099873 @default.
• W2992783192 cites W1986701040 @default.
• W2992783192 cites W1992618206 @default.
• W2992783192 cites W2004829543 @default.
• W2992783192 cites W2044601662 @default.
• W2992783192 cites W2072154203 @default.
• W2992783192 cites W2105374417 @default.
• W2992783192 cites W2119395796 @default.
• W2992783192 cites W2144691565 @default.
• W2992783192 cites W2145092426 @default.
• W2992783192 cites W2161032069 @default.
• W2992783192 cites W2175790457 @default.
• W2992783192 cites W2511789742 @default.
• W2992783192 cites W2525353062 @default.
• W2992783192 cites W2538061776 @default.
• W2992783192 cites W2594982122 @default.
• W2992783192 cites W2755247107 @default.
• W2992783192 cites W2790519321 @default.
• W2992783192 cites W2805088892 @default.
• W2992783192 cites W2883906054 @default.
• W2992783192 doi "https://doi.org/10.1186/s12885-019-6351-4" @default.
• W2992783192 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6896664" @default.
• W2992783192 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31805975" @default.
• W2992783192 hasPublicationYear "2019" @default.
• W2992783192 type Work @default.
• W2992783192 sameAs 2992783192 @default.
• W2992783192 citedByCount "4" @default.
• W2992783192 countsByYear W29927831922022 @default.
• W2992783192 countsByYear W29927831922023 @default.
• W2992783192 crossrefType "journal-article" @default.
• W2992783192 hasAuthorship W2992783192A5003046062 @default.
• W2992783192 hasAuthorship W2992783192A5012626231 @default.
• W2992783192 hasAuthorship W2992783192A5025018891 @default.
• W2992783192 hasAuthorship W2992783192A5032071728 @default.
• W2992783192 hasAuthorship W2992783192A5040388481 @default.
• W2992783192 hasBestOaLocation W29927831921 @default.
• W2992783192 hasConcept C126838900 @default.
• W2992783192 hasConcept C141071460 @default.
• W2992783192 hasConcept C142724271 @default.
• W2992783192 hasConcept C143998085 @default.
• W2992783192 hasConcept C2776694085 @default.
• W2992783192 hasConcept C2778256501 @default.
• W2992783192 hasConcept C2778754067 @default.
• W2992783192 hasConcept C2779217266 @default.
• W2992783192 hasConcept C2780140570 @default.
• W2992783192 hasConcept C2780668389 @default.
• W2992783192 hasConcept C2781082889 @default.
• W2992783192 hasConcept C509974204 @default.
• W2992783192 hasConcept C71924100 @default.
• W2992783192 hasConceptScore W2992783192C126838900 @default.
• W2992783192 hasConceptScore W2992783192C141071460 @default.
• W2992783192 hasConceptScore W2992783192C142724271 @default.
• W2992783192 hasConceptScore W2992783192C143998085 @default.
• W2992783192 hasConceptScore W2992783192C2776694085 @default.
• W2992783192 hasConceptScore W2992783192C2778256501 @default.
• W2992783192 hasConceptScore W2992783192C2778754067 @default.
• W2992783192 hasConceptScore W2992783192C2779217266 @default.
• W2992783192 hasConceptScore W2992783192C2780140570 @default.
• W2992783192 hasConceptScore W2992783192C2780668389 @default.
• W2992783192 hasConceptScore W2992783192C2781082889 @default.
• W2992783192 hasConceptScore W2992783192C509974204 @default.
• W2992783192 hasConceptScore W2992783192C71924100 @default.
• W2992783192 hasIssue "1" @default.
• W2992783192 hasLocation W29927831921 @default.
• W2992783192 hasLocation W29927831922 @default.
• W2992783192 hasLocation W29927831923 @default.
• W2992783192 hasLocation W29927831924 @default.
• W2992783192 hasOpenAccess W2992783192 @default.
• W2992783192 hasPrimaryLocation W29927831921 @default.
• W2992783192 hasRelatedWork W20089819 @default.
• W2992783192 hasRelatedWork W2026832950 @default.
• W2992783192 hasRelatedWork W2033077696 @default.
• W2992783192 hasRelatedWork W2074316965 @default.
• W2992783192 hasRelatedWork W2154392881 @default.
• W2992783192 hasRelatedWork W2188035050 @default.
• W2992783192 hasRelatedWork W2321173436 @default.
• W2992783192 hasRelatedWork W2397262332 @default.
• W2992783192 hasRelatedWork W2992783192 @default.
• W2992783192 hasRelatedWork W4236091634 @default.
• W2992783192 hasVolume "19" @default.
• W2992783192 isParatext "false" @default.
• W2992783192 isRetracted "false" @default.
• W2992783192 magId "2992783192" @default.
• W2992783192 workType "article" @default.