FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2992783993> ?p ?o ?g. }

• W2992783993 endingPage "248" @default.
• W2992783993 startingPage "235" @default.
• W2992783993 abstract "Glial scars formed after brain injuries provide permissive cues for endogenous neural precursor/stem cells (eNP/SCs) to undergo astrogenesis rather than neurogenesis. Following brain injury, eNP/SCs from the subventricular zone leave their niche, migrate to the injured cortex, and differentiate into reactive astrocytes that contribute to glial scar formation. In vivo neuronal reprogramming, directly converting non-neuronal cells such as reactive astrocytes or NG2 glia into neurons, has greatly improved brain injury repair strategies. However, reprogramming carries a high risk of future clinical applications such as tumorigenicity, involving virus. In this study, we constructed a neural matrix to alter the adverse niche at the injured cortex, enabling eNP/SCs to differentiate into functional neurons. We found that the neural matrix functioned as a “glial trap” that largely concentrated and limited reactive astrocytes to the core of the lesion area, thus altering the adverse niche. The eNP/SCs migrated toward the injured cortex and differentiated into functional neurons. In addition, regenerated neurites extended across the boundary of the injured cortex. Mice treated with the neural matrix demonstrated significant behavioral recovery. For the first time, we induced eNP/SC-derived functional neurons in the cortex after brain injury without the use of viruses, microRNAs, or small molecules. Our novel strategy of applying this “glial trap” to obtain functional neurons in the injured cortex may provide a safer and more natural therapeutic alternative to reprogramming in future clinical applications." @default.
• W2992783993 created "2019-12-13" @default.
• W2992783993 creator A5001769423 @default.
• W2992783993 creator A5024357752 @default.
• W2992783993 creator A5032349987 @default.
• W2992783993 creator A5036164591 @default.
• W2992783993 creator A5044941594 @default.
• W2992783993 creator A5089177966 @default.
• W2992783993 creator A5089681600 @default.
• W2992783993 date "2020-02-15" @default.
• W2992783993 modified "2023-09-25" @default.
• W2992783993 title "Neurogenic Niche Conversion Strategy Induces Migration and Functional Neuronal Differentiation of Neural Precursor Cells Following Brain Injury" @default.
• W2992783993 cites W1522823711 @default.
• W2992783993 cites W1542736629 @default.
• W2992783993 cites W1586855301 @default.
• W2992783993 cites W1806909159 @default.
• W2992783993 cites W1971526742 @default.
• W2992783993 cites W1972199597 @default.
• W2992783993 cites W1975032719 @default.
• W2992783993 cites W1977934887 @default.
• W2992783993 cites W1980514743 @default.
• W2992783993 cites W1982539946 @default.
• W2992783993 cites W1983955843 @default.
• W2992783993 cites W1987618226 @default.
• W2992783993 cites W1988875977 @default.
• W2992783993 cites W1988896202 @default.
• W2992783993 cites W1997896450 @default.
• W2992783993 cites W2003174281 @default.
• W2992783993 cites W2007040008 @default.
• W2992783993 cites W2007242343 @default.
• W2992783993 cites W2010441495 @default.
• W2992783993 cites W2012928251 @default.
• W2992783993 cites W2017830127 @default.
• W2992783993 cites W2021442315 @default.
• W2992783993 cites W2023778684 @default.
• W2992783993 cites W2035250926 @default.
• W2992783993 cites W2036068585 @default.
• W2992783993 cites W2044224616 @default.
• W2992783993 cites W2046193777 @default.
• W2992783993 cites W2046333974 @default.
• W2992783993 cites W2067629356 @default.
• W2992783993 cites W2077439063 @default.
• W2992783993 cites W2084652820 @default.
• W2992783993 cites W2089771991 @default.
• W2992783993 cites W2090249462 @default.
• W2992783993 cites W2090989957 @default.
• W2992783993 cites W2095546080 @default.
• W2992783993 cites W2096796354 @default.
• W2992783993 cites W2099134671 @default.
• W2992783993 cites W2104719009 @default.
• W2992783993 cites W2104968232 @default.
• W2992783993 cites W2124019758 @default.
• W2992783993 cites W2129743419 @default.
• W2992783993 cites W2135395238 @default.
• W2992783993 cites W2136541538 @default.
• W2992783993 cites W2142509200 @default.
• W2992783993 cites W2145583720 @default.
• W2992783993 cites W2147611467 @default.
• W2992783993 cites W2160935383 @default.
• W2992783993 cites W2163987873 @default.
• W2992783993 cites W2176412441 @default.
• W2992783993 cites W220677012 @default.
• W2992783993 cites W2585765664 @default.
• W2992783993 cites W2807892837 @default.
• W2992783993 cites W2818969815 @default.
• W2992783993 cites W2887009538 @default.
• W2992783993 cites W2897400127 @default.
• W2992783993 cites W2901405426 @default.
• W2992783993 cites W2913211528 @default.
• W2992783993 cites W2914762501 @default.
• W2992783993 cites W2935350269 @default.
• W2992783993 cites W2950484445 @default.
• W2992783993 cites W2952481707 @default.
• W2992783993 cites W2955578490 @default.
• W2992783993 cites W3146327943 @default.
• W2992783993 cites W4239583753 @default.
• W2992783993 doi "https://doi.org/10.1089/scd.2019.0147" @default.
• W2992783993 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31797735" @default.
• W2992783993 hasPublicationYear "2020" @default.
• W2992783993 type Work @default.
• W2992783993 sameAs 2992783993 @default.
• W2992783993 citedByCount "7" @default.
• W2992783993 countsByYear W29927839932020 @default.
• W2992783993 countsByYear W29927839932021 @default.
• W2992783993 countsByYear W29927839932022 @default.
• W2992783993 countsByYear W29927839932023 @default.
• W2992783993 crossrefType "journal-article" @default.
• W2992783993 hasAuthorship W2992783993A5001769423 @default.
• W2992783993 hasAuthorship W2992783993A5024357752 @default.
• W2992783993 hasAuthorship W2992783993A5032349987 @default.
• W2992783993 hasAuthorship W2992783993A5036164591 @default.
• W2992783993 hasAuthorship W2992783993A5044941594 @default.
• W2992783993 hasAuthorship W2992783993A5089177966 @default.
• W2992783993 hasAuthorship W2992783993A5089681600 @default.
• W2992783993 hasBestOaLocation W29927839931 @default.
• W2992783993 hasConcept C136834591 @default.
• W2992783993 hasConcept C1491633281 @default.
• W2992783993 hasConcept C169760540 @default.

• next