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- W2992786372 abstract "The effects of the methanol extracts of the leaves of Phyllanthusamarus on the sperm parameters of male Guinea pigs were investigated.The effects of Vitamin E on the sperm parameters were also investigatedand compared to that of Phyllanthus amarus. The phytochemical screeningof the leaves of Phyllanthus amarus was also carried out. The methanolextract of the Phyllanthus amarus leaf (50-200mg/kg) caused a decreasein the sperm count and motility, from 65.0± 2.80 and66.7±0.33 to 46.0± 2.10 and 37.7± 1.50 respectively.However, this effect was less pronounced at higher doses of Phyllanthusamarus (400 and 800mg/kg). At 400 and 800mg/kg, P. amarus caused adecrease in sperm motility and count from 65.0±2.50 and 66.7±1.5 to 52.7± 0.50 and 56.7± 0.80 : to 43.3±1.70 and48.3±1.70 respectively . These effects were dose- dependent andcomparable to the observed effects of Vitamin E (500IU) on spermparameters of male guinea pigs. These were significant at P < 0.05(ANOVA). In timedependent study, the observed effect of P. amarus(800mg/kg) and Vitamin E on the values of sperm count and motility at28 day were almost the same. These values are 56.7± 3.30 and48.3± 1.70 for vitamin E; 47.5±2.50 and 47.5± 2.50 forP.amarus respectively for sperm motility and count. These effects weretime- dependent and statistically significant at P < 0.05 (ANOVA).Finally, the phytochemical screening of the leaves of Phyllanthusamarus revealed the presence of flavonoids, tannins, alkaloids,terpenoids, steroids, saponins and cardiac glycosides. This shows thatthe leaves of P .amarus do not largely contribute direct to the claimson the use of the aerial part of this plant by traditional medicinepractitioners to increase/improve libido in men but it may have someindirect beneficial effects on this claim (like antioxidant activity)that mimic Vitamin E in both action and mechanism of action. However,further studies need to be done to investigate the contribution of theseeds of this plant in the improvement of libido in men and to isolateand characterize the active principles in the extracts of this plant. @JASEM" @default.
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- W2992786372 date "2009-07-01" @default.
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- W2992786372 title "The comparative effects of methanol extract of Phyllanthus amarus leaves and Vitamin E on the Sperm parameters of Male guinea pigs" @default.
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