Matches in SemOpenAlex for { <https://semopenalex.org/work/W2992803755> ?p ?o ?g. }
- W2992803755 endingPage "107908" @default.
- W2992803755 startingPage "107908" @default.
- W2992803755 abstract "Tuberous sclerosis complex (TSC) is an autosomal dominant neurocutaneous disorder affecting approximately 1 in 6,000 in general population and represents one of the most common genetic causes of epilepsy. Epilepsy affects 90% of the patients and appears in the first 2 years of life in the majority of them. Early onset of epilepsy in the first year of life is associated with high risk of cognitive decline and neuropsychiatric problems including autism. Recently TSC has been recognized as a model of genetic epilepsies. TSC is a genetic condition with known dysregulated mTOR pathway and is increasingly viewed as a model for human epileptogenesis. Moreover, TSC is characterized by a hyperactivation of mTOR (mammalian target of rapamycin) pathway, and mTOR activation was showed to be implicated in epileptogenesis in many animal models and human epilepsies. Recently published studies documented positive effect of preventive or disease modifying treatment of epilepsy in infants with high risk of epilepsy with significantly lower incidence of epilepsy and better cognitive outcome. Further studies on preventive treatment of epilepsy in other genetic epilepsies of early childhood are considered. This article is part of the special issue entitled 'New Epilepsy Therapies for the 21st Century - From Antiseizure Drugs to Prevention, Modification and Cure of Epilepsy'." @default.
- W2992803755 created "2019-12-13" @default.
- W2992803755 creator A5005801531 @default.
- W2992803755 creator A5016714520 @default.
- W2992803755 creator A5028077452 @default.
- W2992803755 creator A5058587345 @default.
- W2992803755 date "2020-04-01" @default.
- W2992803755 modified "2023-10-14" @default.
- W2992803755 title "Modifying genetic epilepsies – Results from studies on tuberous sclerosis complex" @default.
- W2992803755 cites W1516172702 @default.
- W2992803755 cites W1520014842 @default.
- W2992803755 cites W1574898460 @default.
- W2992803755 cites W1578183568 @default.
- W2992803755 cites W1585670565 @default.
- W2992803755 cites W1745175653 @default.
- W2992803755 cites W1803495774 @default.
- W2992803755 cites W1886226115 @default.
- W2992803755 cites W1972016035 @default.
- W2992803755 cites W1978437325 @default.
- W2992803755 cites W1986442348 @default.
- W2992803755 cites W2003741148 @default.
- W2992803755 cites W2010425177 @default.
- W2992803755 cites W2017245404 @default.
- W2992803755 cites W2020209656 @default.
- W2992803755 cites W2020372671 @default.
- W2992803755 cites W2024191529 @default.
- W2992803755 cites W2026430274 @default.
- W2992803755 cites W2029598577 @default.
- W2992803755 cites W2035495486 @default.
- W2992803755 cites W2038026687 @default.
- W2992803755 cites W2056111473 @default.
- W2992803755 cites W2062000411 @default.
- W2992803755 cites W2064721084 @default.
- W2992803755 cites W2073685367 @default.
- W2992803755 cites W2080090598 @default.
- W2992803755 cites W2087441158 @default.
- W2992803755 cites W2088237695 @default.
- W2992803755 cites W2091406481 @default.
- W2992803755 cites W2092491756 @default.
- W2992803755 cites W2093650339 @default.
- W2992803755 cites W2101002011 @default.
- W2992803755 cites W2105558792 @default.
- W2992803755 cites W2111444310 @default.
- W2992803755 cites W2118583212 @default.
- W2992803755 cites W2119856985 @default.
- W2992803755 cites W2119967224 @default.
- W2992803755 cites W2126467306 @default.
- W2992803755 cites W2136118907 @default.
- W2992803755 cites W2139185747 @default.
- W2992803755 cites W2140657162 @default.
- W2992803755 cites W2142533388 @default.
- W2992803755 cites W2153879992 @default.
- W2992803755 cites W2167665957 @default.
- W2992803755 cites W2169126479 @default.
- W2992803755 cites W2213393418 @default.
- W2992803755 cites W2259261531 @default.
- W2992803755 cites W2261274039 @default.
- W2992803755 cites W2341766265 @default.
- W2992803755 cites W2511912940 @default.
- W2992803755 cites W2582025421 @default.
- W2992803755 cites W2583795843 @default.
- W2992803755 cites W2588870577 @default.
- W2992803755 cites W2593816418 @default.
- W2992803755 cites W2607013389 @default.
- W2992803755 cites W2608937503 @default.
- W2992803755 cites W2618612696 @default.
- W2992803755 cites W2726630066 @default.
- W2992803755 cites W2731240182 @default.
- W2992803755 cites W2766480612 @default.
- W2992803755 cites W278209533 @default.
- W2992803755 cites W2790156980 @default.
- W2992803755 cites W2791224214 @default.
- W2992803755 cites W2796271887 @default.
- W2992803755 cites W2800035737 @default.
- W2992803755 cites W2800447375 @default.
- W2992803755 cites W2803742210 @default.
- W2992803755 cites W2808053580 @default.
- W2992803755 cites W2810916581 @default.
- W2992803755 cites W2892988385 @default.
- W2992803755 cites W2894432237 @default.
- W2992803755 cites W2894594324 @default.
- W2992803755 cites W2900828529 @default.
- W2992803755 cites W2913055551 @default.
- W2992803755 cites W2925890589 @default.
- W2992803755 cites W2982862638 @default.
- W2992803755 cites W31048558 @default.
- W2992803755 cites W4256397550 @default.
- W2992803755 doi "https://doi.org/10.1016/j.neuropharm.2019.107908" @default.
- W2992803755 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31962286" @default.
- W2992803755 hasPublicationYear "2020" @default.
- W2992803755 type Work @default.
- W2992803755 sameAs 2992803755 @default.
- W2992803755 citedByCount "29" @default.
- W2992803755 countsByYear W29928037552020 @default.
- W2992803755 countsByYear W29928037552021 @default.
- W2992803755 countsByYear W29928037552022 @default.
- W2992803755 countsByYear W29928037552023 @default.
- W2992803755 crossrefType "journal-article" @default.