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- W2992850929 abstract "First, parallels are drawn between the conduct of clinical trials and a few events in history that share a management style known as top-down management or a hierarchal decision-making process. The author suggests that this process isolates investigative sites from sponsors and contributes to the failure of clinical trials. Trial design, patient recruitment, site selection, the use of electronic data devices, and enrollment timelines are examined in greater detail. Suggestions for a more open or shared process are offered, with the belief that fewer trials might fail and fewer questions might remain in the case of those that do.Next, in the companion commentary, some of the problems arising in drug development and clinical trials are mentioned along with a partial listing of solution providers. An outline of circumstances involved in the decision-making process in drug development are presented along with some factors leading to decreased signal detection." @default.
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- W2992850929 date "2012-02-01" @default.
- W2992850929 modified "2023-09-23" @default.
- W2992850929 title "It's only a little ice: a personal view with companion commentary." @default.
- W2992850929 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3312899" @default.
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