Matches in SemOpenAlex for { <https://semopenalex.org/work/W2992878120> ?p ?o ?g. }
- W2992878120 endingPage "276" @default.
- W2992878120 startingPage "263" @default.
- W2992878120 abstract "Neurodegenerative diseases require characterization based on underlying biology using biochemical biomarkers. Mixed pathology complicates discovery of biomarkers and characterization of cohorts, but inclusion of greater numbers of patients with different, related diseases with frequently co-occurring pathology could allow better accuracy. Combining cohorts collected from different studies would be a more efficient use of resources than recruiting subjects from each population of interest for each study.To explore the possibility of combining existing datasets by controlling pre-analytic variables in the Alzheimer's Disease Neuroimaging Initiative (ADNI) and Parkinson's Progression Markers Initiative (PPMI) studies.Cerebrospinal fluid (CSF) was collected and processed from 30 subjects according to both the ADNI and PPMI protocols. Relationships between reported levels of Alzheimer's disease (AD) and Parkinson's disease (PD) biomarkers in the same subject under each protocol were examined.Protocol-related differences were observed for Aβ, but not t-tau or α-syn, and trended different for p-tau and pS129. Values of α-syn differed by platform. Conversion of α-syn values between ADNI and PPMI platforms did not completely eliminate differences in distribution.Factors not captured in the pre-analytical sample handling influence reported biomarker values. Assay standardization and better harmonized characterization of cohorts should be included in future studies of CSF biomarkers." @default.
- W2992878120 created "2019-12-13" @default.
- W2992878120 creator A5004855604 @default.
- W2992878120 creator A5016122096 @default.
- W2992878120 creator A5016305380 @default.
- W2992878120 creator A5018100435 @default.
- W2992878120 creator A5021394368 @default.
- W2992878120 creator A5023136222 @default.
- W2992878120 creator A5024057845 @default.
- W2992878120 creator A5042614154 @default.
- W2992878120 creator A5067989531 @default.
- W2992878120 creator A5078844871 @default.
- W2992878120 creator A5088737186 @default.
- W2992878120 creator A5089163938 @default.
- W2992878120 date "2019-05-07" @default.
- W2992878120 modified "2023-09-22" @default.
- W2992878120 title "Impact of Pre-Analytical Differences on Biomarkers in the ADNI and PPMI Studies: Implications in the Era of Classifying Disease Based on Biomarkers" @default.
- W2992878120 cites W1447565288 @default.
- W2992878120 cites W1573440420 @default.
- W2992878120 cites W1919825598 @default.
- W2992878120 cites W1982834182 @default.
- W2992878120 cites W1983874275 @default.
- W2992878120 cites W1984033486 @default.
- W2992878120 cites W2008051097 @default.
- W2992878120 cites W2008301592 @default.
- W2992878120 cites W2015020748 @default.
- W2992878120 cites W2015484447 @default.
- W2992878120 cites W2016123010 @default.
- W2992878120 cites W2018871318 @default.
- W2992878120 cites W2022163852 @default.
- W2992878120 cites W2023015631 @default.
- W2992878120 cites W2033132890 @default.
- W2992878120 cites W2033572099 @default.
- W2992878120 cites W2050629539 @default.
- W2992878120 cites W2050922537 @default.
- W2992878120 cites W2059160347 @default.
- W2992878120 cites W2066155243 @default.
- W2992878120 cites W2075193321 @default.
- W2992878120 cites W2077399174 @default.
- W2992878120 cites W2104954974 @default.
- W2992878120 cites W2108475007 @default.
- W2992878120 cites W2112099976 @default.
- W2992878120 cites W2124670646 @default.
- W2992878120 cites W2132881915 @default.
- W2992878120 cites W2134113727 @default.
- W2992878120 cites W2137570301 @default.
- W2992878120 cites W2146618600 @default.
- W2992878120 cites W2156220037 @default.
- W2992878120 cites W2160719857 @default.
- W2992878120 cites W2192217112 @default.
- W2992878120 cites W2260519762 @default.
- W2992878120 cites W2330640534 @default.
- W2992878120 cites W2385703614 @default.
- W2992878120 cites W2621864910 @default.
- W2992878120 cites W2791984994 @default.
- W2992878120 cites W2797129551 @default.
- W2992878120 cites W950120787 @default.
- W2992878120 doi "https://doi.org/10.3233/jad-190069" @default.
- W2992878120 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6513710" @default.
- W2992878120 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30958379" @default.
- W2992878120 hasPublicationYear "2019" @default.
- W2992878120 type Work @default.
- W2992878120 sameAs 2992878120 @default.
- W2992878120 citedByCount "11" @default.
- W2992878120 countsByYear W29928781202020 @default.
- W2992878120 countsByYear W29928781202021 @default.
- W2992878120 countsByYear W29928781202022 @default.
- W2992878120 countsByYear W29928781202023 @default.
- W2992878120 crossrefType "journal-article" @default.
- W2992878120 hasAuthorship W2992878120A5004855604 @default.
- W2992878120 hasAuthorship W2992878120A5016122096 @default.
- W2992878120 hasAuthorship W2992878120A5016305380 @default.
- W2992878120 hasAuthorship W2992878120A5018100435 @default.
- W2992878120 hasAuthorship W2992878120A5021394368 @default.
- W2992878120 hasAuthorship W2992878120A5023136222 @default.
- W2992878120 hasAuthorship W2992878120A5024057845 @default.
- W2992878120 hasAuthorship W2992878120A5042614154 @default.
- W2992878120 hasAuthorship W2992878120A5067989531 @default.
- W2992878120 hasAuthorship W2992878120A5078844871 @default.
- W2992878120 hasAuthorship W2992878120A5088737186 @default.
- W2992878120 hasAuthorship W2992878120A5089163938 @default.
- W2992878120 hasBestOaLocation W29928781202 @default.
- W2992878120 hasConcept C104317684 @default.
- W2992878120 hasConcept C124535831 @default.
- W2992878120 hasConcept C142724271 @default.
- W2992878120 hasConcept C143998085 @default.
- W2992878120 hasConcept C15744967 @default.
- W2992878120 hasConcept C169760540 @default.
- W2992878120 hasConcept C204787440 @default.
- W2992878120 hasConcept C2778373026 @default.
- W2992878120 hasConcept C2779134260 @default.
- W2992878120 hasConcept C2779734285 @default.
- W2992878120 hasConcept C2780385302 @default.
- W2992878120 hasConcept C2781197716 @default.
- W2992878120 hasConcept C2908647359 @default.
- W2992878120 hasConcept C46111723 @default.
- W2992878120 hasConcept C502032728 @default.
- W2992878120 hasConcept C54355233 @default.