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• W2992888134 abstract "<p><strong>Objective: </strong>Alzheimer’s disease a progressive neurodegenerative disorder affected by the formation of amyloid beta and tau proteins. Medicinal plants have been proved significantly for its anti-oxidant and anti-inflammatory activity that might help in treating neurological disorders. Curcumin has been hugely studied in the treatment of various ailments but its water solubility and bioavailability is still a concern but we have tried to exterminate the problem by our formulation CUR-CA-THIONE. Now, we have expanded the study of CUR-CA-THIONE for its neuroprotective estimation by evaluating behavioral, biochemical and histopathological assessment in rats.</p><p><strong>Methods: </strong>Wistar rats of either sex (M/F: 25-350g; 350-450 g) were selected for study and divided into 8 groups. All animals except NC were given aluminum chloride via oral route throughout the study period (30 d) while group 3-8 received treatment one-hour post aluminum chloride induction from 15^th day to 30^th day. One week prior to the start of the experiment all animals were given training for behavioral assessment through y-maze and morris water maze with the weekly assessment. On 30^th-day post completion of study rat brain was isolated to study biochemical and histopathological examination.</p><p><strong>Results: </strong>The results of the behavioral assessment in CUR-CA-THIONE complex showed an increase in total arm entries in Y-maze and decrease in time duration for morris water maze test. A significant (p&lt;0.01) decrease in lipid peroxidation, superoxide dismutase, acetylcholine and total protein levels in formulations while significant (p&lt;0.01) increase in glutathione and catalase level was observed.</p><p><strong>Conclusion: </strong>The given formulation shows that curcumin-casein-glutathione complex shows potential action as a neuroprotective effect.</p><p> </p>" @default.
• W2992888134 created "2019-12-13" @default.
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• W2992888134 date "2016-12-01" @default.
• W2992888134 modified "2023-10-04" @default.
• W2992888134 title "NEUROPROTECTIVE ACTIVITY OF NOVEL CUR-CA-THIONE AND ITS OXIDATIVE STRESS STUDY" @default.
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• W2992888134 doi "https://doi.org/10.22159/ijpps.2016v8i12.15141" @default.
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