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- W2992943022 abstract "We have studied 18 patients with myeloproliferative disorders to determine whether their abnormal platelet function and increased plasma β thromboglobulin (β TG) are associated with activated coagulation and fibrinolytic systems. Of these patients, 8 had polycythaemia rubra vera, 8 had myelofibrosis and 2 had thrombocythaemia. We measured plasma concentrations of the thrombin sensitive fragment fibrinopeptide A (FPA), the plasmin sensitive fibrinogen fragment B β1-42, and β TG by radioimmunoassay. We also studied platelet aggregation in response to ADP. Mean normal values (n = 20) for FpA, B β1-42 and βTG were 1.06, 1.59 and 0.80 pmol/ml respectively. The 18 patients showed minimal plasma thrombin and plasmin activities with a disproportionately large platelet release. Mean FpA, B β1-42 and β TG levels were 1.74, 3.31 and 3.12 pmol/ml, respectively. These patients exhibited increased, decreased and normal platelet aggregation but no specific defect was associated with any particular radioimmunoassay result. 5 of these patients, 4 of whom had increased aggregation, were treated with aspirin in sufficient doses to eliminate their secondary response to ADP. FPA and B β1-42 were not altered but β TG was reduced from 3.39 to 2.72 pmol/ml. We also studied 10 patients with idiopathic polycythaemia. These patients showed a normal platelet response to ADP. Their FPA, B β1-42 and β TG levels were similar to normal, 0.7, 1.93 and 0.97 pmol/ml respectively. We conclude that in myeloproliferative disorders (a) the increased plasma concentration of β TG is not associated with a particular platelet aggregation abnormality (b) in the majority of patients the increased β TG level is not a consequence of thrombin action (c) the raised FpA and B β1-42 plasma levels in the minority of patients cannot be attributed solely to increased red cell mass (d) much of the β TG release is probably independent of the cyclooxygenase pathway." @default.
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- W2992943022 date "1981-01-01" @default.
- W2992943022 modified "2023-09-26" @default.
- W2992943022 title "Fibrinogen Proteolysis And Platelet Activation In Myeloproliferative Disorders" @default.
- W2992943022 doi "https://doi.org/10.1055/s-0038-1652037" @default.
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