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- W2993077065 abstract "Native factor VII (F. VIIn) can be activated by thromboplastin or by the kallikrein-system. This gives rise to two different forms of activated factor VII. We thus discern Factor VIIn, cold activated factor VII (C.P.A-F. VIIa) and thromboplastin activated factor VII (T-F. VIIa). We developed one- and two-stage assays that distinguish between these forms and we tried to establish their interrelationship. T-F. VIIa could be obtained in a form devoid of lipid components and still clearly distinguishable both from factor VIIn and from C.P.A.-F. VIIa. It activates factor X in a thromboplastin-independent process, whereas C.P.A.-F. VIIa is unable to do so. The difference between F. VIIn and C.P.A.-F. VIIa is that the latter is converted into T-F. VIIa much more quickly in a process that shows less species specificity with regard to the type of thromboplastin used. No differences could be seen between T-F. VIIa obtained from V, VIIn directly or via C.P.A.-F. VIIa." @default.
- W2993077065 created "2019-12-13" @default.
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- W2993077065 date "1975-01-01" @default.
- W2993077065 modified "2023-09-23" @default.
- W2993077065 title "The Activation of Factor VII" @default.
- W2993077065 doi "https://doi.org/10.1055/s-0039-1689644" @default.
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