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• W2993097788 startingPage "4416" @default.
• W2993097788 abstract "Salvianolic acid B is one of the main water-soluble components of Salvia miltiorrhiza Bge. Many reports have shown that it has significant anti-myocardial ischemia effect. However, the underlying mechanism remains unclear. Our present study demonstrated that Sal B could alleviate myocardial ischemic injury by inhibiting the priming phase of NLRP3 inflammasome. In vivo, serum c-troponin I (cTn), lactate dehydrogenase (LDH) levels, the cardiac function and infract size were examined. We found that Sal B could notably reduce the myocardial ischemic injury caused by ligation of the left anterior descending coronary artery. In vitro, Sal B down-regulated the TLR4/NF-κB signaling cascades in lipopolysaccharide (LPS)-stimulated H9C2 cells. Furthermore, Sal B reduced the expression levels of IL-1β and NLRP3 inflammasome in a dose-dependent manner. In short, our study provided evidence that Sal B could attenuate myocardial ischemic injury via inhibition of TLR4/NF-κB/NLRP3 signaling pathway. And in an upstream level, MD-2 may be the potential target." @default.
• W2993097788 created "2019-12-13" @default.
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• W2993097788 date "2019-12-03" @default.
• W2993097788 modified "2023-10-07" @default.
• W2993097788 title "Sal B Alleviates Myocardial Ischemic Injury by Inhibiting TLR4 and the Priming Phase of NLRP3 Inflammasome" @default.
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• W2993097788 doi "https://doi.org/10.3390/molecules24234416" @default.
• W2993097788 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6930479" @default.
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