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- W2993115598 abstract "GHK (Gly-His-Lys), a natural peptide found in human skin and plasma, has been widely used in the cosmeceutical and pharmaceutical fields. The hydrophilic GHK and GHK-Cu are limited in their abilities to penetrate deeply into skin; because of this, various strategies for their skin delivery have been developed. In this investigation, Arg4 was conjugated with GHK to get heptapeptide, GHK-R4, and then in vitro antiwrinkle activity and transdermal delivery were compared between GHK and GHK-R4. Notably, Arg4 conjugation accelerated the cellular penetration of GHK both in vitro and in vivo. Furthermore, higher in vitro antiwrinkle activity and collagen biosynthesis was obtained with GHK-R4 at much lower doses than with control R4-free GHK. The enhanced activity and delivery of GHK-R4 might be due to the cell penetrating ability and matrix metalloproteinase (MMP) inhibitory activity of R4 itself." @default.
- W2993115598 created "2019-12-13" @default.
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- W2993115598 date "2019-12-01" @default.
- W2993115598 modified "2023-09-27" @default.
- W2993115598 title "Effect of oligoarginine conjugation on the antiwrinkle activity and transdermal delivery of GHK peptide" @default.
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- W2993115598 doi "https://doi.org/10.1002/psc.3234" @default.
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