FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2993143090> ?p ?o ?g. }

• W2993143090 endingPage "105661" @default.
• W2993143090 startingPage "105661" @default.
• W2993143090 abstract "Ectonucleotide pyrophosphate phosphodiesterase type II (ENPP2), also known as Autotaxin (ATX), is an enzyme present in blood circulation that converts lysophosphatidyl choline (LPC) to lysophosphatidic acid (LPA). While LPA has been demonstrated to play diverse roles in skeletal myogenesis, mainly through in vitro studies, the role of ENPP2 in skeletal myogenesis has not been determined. We previously found that Enpp2 is induced by a positive WNT/β-Catenin signaling regulator, R-spondin2 (RSPO2), in C2C12 myoblast cells. As RSPO2 promotes myogenic differentiation via the WNT/β-Catenin signaling pathway, we hypothesized that ENPP2 may act as a key mediator for the crosstalk between WNT and LPA signaling during myogenic differentiation. Herein, we found that ENPP2 function is essential for myogenic differentiation in C2C12 cells. Pharmacological ENPP2 inhibitors or RNAi-mediated Enpp2 gene knockdown severely impaired the myogenic differentiation, including the cell fusion process, whereas administration of the recombinant ENPP2 protein enhanced myogenic differentiation. Consistent with the in vitro results, mice lacking the Enpp2 gene showed a disrupted muscle regeneration after acute muscle injury. The size of newly regenerated myofibers in Enpp2 mutant muscle was significantly reduced compared with wild-type regenerated muscle. Modified expression patterns of myogenic markers in Enpp2 mutant muscle further emphasized the impaired muscle regeneration process. Finally, we convincingly demonstrate that the Enpp2 gene is a direct transcriptional target for WNT/β-Catenin signaling. Functional TCF/LEF1 binding sites within the upstream region of Enpp2 gene were identified by chromatin immunoprecipitation using anti-β-Catenin antibodies and reporter assay. Our study reveals that ENPP2 is regulated by WNT/β-Catenin signaling and plays a key positive role in myogenic differentiation." @default.
• W2993143090 created "2019-12-13" @default.
• W2993143090 creator A5007486155 @default.
• W2993143090 creator A5009086826 @default.
• W2993143090 creator A5025566125 @default.
• W2993143090 creator A5039423171 @default.
• W2993143090 creator A5056896463 @default.
• W2993143090 creator A5067515573 @default.
• W2993143090 creator A5075275616 @default.
• W2993143090 date "2020-01-01" @default.
• W2993143090 modified "2023-09-27" @default.
• W2993143090 title "Ectonucleotide pyrophosphatase 2 (ENPP2) plays a crucial role in myogenic differentiation through the regulation by WNT/β-Catenin signaling" @default.
• W2993143090 cites W1495188240 @default.
• W2993143090 cites W1535466977 @default.
• W2993143090 cites W1974170084 @default.
• W2993143090 cites W1975291066 @default.
• W2993143090 cites W1987833161 @default.
• W2993143090 cites W1992192668 @default.
• W2993143090 cites W1995087657 @default.
• W2993143090 cites W1998134241 @default.
• W2993143090 cites W1999145831 @default.
• W2993143090 cites W2010110193 @default.
• W2993143090 cites W2010753629 @default.
• W2993143090 cites W2013377366 @default.
• W2993143090 cites W2020647366 @default.
• W2993143090 cites W2035128865 @default.
• W2993143090 cites W2036221416 @default.
• W2993143090 cites W2036222948 @default.
• W2993143090 cites W2036872645 @default.
• W2993143090 cites W2065484467 @default.
• W2993143090 cites W2075190556 @default.
• W2993143090 cites W2080079782 @default.
• W2993143090 cites W2092846037 @default.
• W2993143090 cites W2094210837 @default.
• W2993143090 cites W2096778432 @default.
• W2993143090 cites W2098773444 @default.
• W2993143090 cites W2099689816 @default.
• W2993143090 cites W2100595555 @default.
• W2993143090 cites W2104490911 @default.
• W2993143090 cites W2108812575 @default.
• W2993143090 cites W2111598714 @default.
• W2993143090 cites W2116859659 @default.
• W2993143090 cites W2117748303 @default.
• W2993143090 cites W2122069948 @default.
• W2993143090 cites W2142673125 @default.
• W2993143090 cites W2146138975 @default.
• W2993143090 cites W2150969249 @default.
• W2993143090 cites W2167283281 @default.
• W2993143090 cites W2517355574 @default.
• W2993143090 cites W2590653380 @default.
• W2993143090 cites W2782149049 @default.
• W2993143090 doi "https://doi.org/10.1016/j.biocel.2019.105661" @default.
• W2993143090 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31805399" @default.
• W2993143090 hasPublicationYear "2020" @default.
• W2993143090 type Work @default.
• W2993143090 sameAs 2993143090 @default.
• W2993143090 citedByCount "13" @default.
• W2993143090 countsByYear W29931430902020 @default.
• W2993143090 countsByYear W29931430902021 @default.
• W2993143090 countsByYear W29931430902022 @default.
• W2993143090 countsByYear W29931430902023 @default.
• W2993143090 crossrefType "journal-article" @default.
• W2993143090 hasAuthorship W2993143090A5007486155 @default.
• W2993143090 hasAuthorship W2993143090A5009086826 @default.
• W2993143090 hasAuthorship W2993143090A5025566125 @default.
• W2993143090 hasAuthorship W2993143090A5039423171 @default.
• W2993143090 hasAuthorship W2993143090A5056896463 @default.
• W2993143090 hasAuthorship W2993143090A5067515573 @default.
• W2993143090 hasAuthorship W2993143090A5075275616 @default.
• W2993143090 hasConcept C126322002 @default.
• W2993143090 hasConcept C134018914 @default.
• W2993143090 hasConcept C137620995 @default.
• W2993143090 hasConcept C170493617 @default.
• W2993143090 hasConcept C185592680 @default.
• W2993143090 hasConcept C207200792 @default.
• W2993143090 hasConcept C2776661833 @default.
• W2993143090 hasConcept C2778106681 @default.
• W2993143090 hasConcept C2778463287 @default.
• W2993143090 hasConcept C37547375 @default.
• W2993143090 hasConcept C3763915 @default.
• W2993143090 hasConcept C55493867 @default.
• W2993143090 hasConcept C62478195 @default.
• W2993143090 hasConcept C71924100 @default.
• W2993143090 hasConcept C86803240 @default.
• W2993143090 hasConcept C95444343 @default.
• W2993143090 hasConceptScore W2993143090C126322002 @default.
• W2993143090 hasConceptScore W2993143090C134018914 @default.
• W2993143090 hasConceptScore W2993143090C137620995 @default.
• W2993143090 hasConceptScore W2993143090C170493617 @default.
• W2993143090 hasConceptScore W2993143090C185592680 @default.
• W2993143090 hasConceptScore W2993143090C207200792 @default.
• W2993143090 hasConceptScore W2993143090C2776661833 @default.
• W2993143090 hasConceptScore W2993143090C2778106681 @default.
• W2993143090 hasConceptScore W2993143090C2778463287 @default.
• W2993143090 hasConceptScore W2993143090C37547375 @default.
• W2993143090 hasConceptScore W2993143090C3763915 @default.
• W2993143090 hasConceptScore W2993143090C55493867 @default.
• W2993143090 hasConceptScore W2993143090C62478195 @default.

• next