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• W2993156713 abstract "Abstract We have developed a new genetically encoded tool designed to generate reactive oxygen species (ROS) at target proteins in cultured cells; it is designed using firefly luciferase and photosensitiser protein KillerRed. Targeting this fusion protein, KillerFirefly, to F-actin in live cells and treatment with luciferin induced a characteristic structure, previously reported as a cofilin-actin rod, which is seen in patients with Alzheimer’s disease. This structural change is considered to be elicited by the consistent generation of very low-level ROS by KillerFirefly in the vicinity of F-actin. Moreover, our results suggest the presence of an actin-regulating system, controlled by very low levels of endogenously generated ROS." @default.
• W2993156713 created "2019-12-13" @default.
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• W2993156713 date "2019-12-03" @default.
• W2993156713 modified "2023-09-25" @default.
• W2993156713 title "A new bioluminescence-based tool for modulating target proteins in live cells" @default.
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• W2993156713 doi "https://doi.org/10.1038/s41598-019-54712-y" @default.
• W2993156713 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6890795" @default.
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