Matches in SemOpenAlex for { <https://semopenalex.org/work/W2993208081> ?p ?o ?g. }
Showing items 1 to 63 of
63
with 100 items per page.
- W2993208081 endingPage "785" @default.
- W2993208081 startingPage "779" @default.
- W2993208081 abstract "This paper aimed to investigate the antibacterial activity of flowers and leaves from Paeonia rockii, screen antibacterial compounds and predict targets of antibacterial to explore its multi-component, multi-target antibacterial mechanism. In this study, minimal inhibitory concentration(MIC) of seven strains of Staphylococcus aureus, S. epidermidis， Bacillus subtilis, B. cereus, Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa were determined by microdilution method. Uniprot databases was used to find the antibacterial targets, and RCSB was used to identify targets associated with antimicrobial activity as docked receptor proteins. The candidate active ingredients from flowers and leaves of P. rockii were identified by database such as PubChem. The ligands were constructed by ChemDraw, Avogadro and Discovery Studio Visualizer. QuickVina 2.0 software was used to molecular docking. Besides, the Cytoscape 3.5.1 software was used to construct activity compounds of flowers and leaves from P. rockii ingredients-targets network, and Uniprot software was used to analyze gene ontology and KEGG pathway. In vitro antibacterial experiments found antibacterial effect of the flowers and leaves from P. rockii, especially methanol extraction of flowers has the strongest antibacterial effect. The network pharmacology indicated that total 29 activity ingredients and their 18 targets were screened in flowers and leaves from P. rockii. Comparison of the active ingredients and the number of antimicrobial target networks, it is predicted that the antibacterial components are mainly flavonoids and phenolic acids and main mechanism of antibacterial is to inhibit the synthesis of bacterial proteins. In this study, potential antibacterial activity of flowers and leaves from P. rockii has be found by antibacterial experiments in vitro and network pharmacology screening. And this study provides new clues for further basic study on the antibacterial agents of flowers and leaves from P. rockii." @default.
- W2993208081 created "2019-12-13" @default.
- W2993208081 creator A5004641378 @default.
- W2993208081 creator A5033632697 @default.
- W2993208081 creator A5046017043 @default.
- W2993208081 creator A5046876145 @default.
- W2993208081 creator A5054919439 @default.
- W2993208081 date "2018-02-01" @default.
- W2993208081 modified "2023-09-25" @default.
- W2993208081 title "[Exploration on antibacterial activity and mechanism of flowers and leaves from Paeonia rockii based on network pharmacology]." @default.
- W2993208081 doi "https://doi.org/10.19540/j.cnki.cjcmm.2018.0020" @default.
- W2993208081 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29600655" @default.
- W2993208081 hasPublicationYear "2018" @default.
- W2993208081 type Work @default.
- W2993208081 sameAs 2993208081 @default.
- W2993208081 citedByCount "0" @default.
- W2993208081 crossrefType "journal-article" @default.
- W2993208081 hasAuthorship W2993208081A5004641378 @default.
- W2993208081 hasAuthorship W2993208081A5033632697 @default.
- W2993208081 hasAuthorship W2993208081A5046017043 @default.
- W2993208081 hasAuthorship W2993208081A5046876145 @default.
- W2993208081 hasAuthorship W2993208081A5054919439 @default.
- W2993208081 hasConcept C158180186 @default.
- W2993208081 hasConcept C2780104969 @default.
- W2993208081 hasConcept C4937899 @default.
- W2993208081 hasConcept C523546767 @default.
- W2993208081 hasConcept C54355233 @default.
- W2993208081 hasConcept C55493867 @default.
- W2993208081 hasConcept C556039675 @default.
- W2993208081 hasConcept C71924100 @default.
- W2993208081 hasConcept C86803240 @default.
- W2993208081 hasConcept C89423630 @default.
- W2993208081 hasConceptScore W2993208081C158180186 @default.
- W2993208081 hasConceptScore W2993208081C2780104969 @default.
- W2993208081 hasConceptScore W2993208081C4937899 @default.
- W2993208081 hasConceptScore W2993208081C523546767 @default.
- W2993208081 hasConceptScore W2993208081C54355233 @default.
- W2993208081 hasConceptScore W2993208081C55493867 @default.
- W2993208081 hasConceptScore W2993208081C556039675 @default.
- W2993208081 hasConceptScore W2993208081C71924100 @default.
- W2993208081 hasConceptScore W2993208081C86803240 @default.
- W2993208081 hasConceptScore W2993208081C89423630 @default.
- W2993208081 hasIssue "4" @default.
- W2993208081 hasLocation W29932080811 @default.
- W2993208081 hasOpenAccess W2993208081 @default.
- W2993208081 hasPrimaryLocation W29932080811 @default.
- W2993208081 hasRelatedWork W1985232253 @default.
- W2993208081 hasRelatedWork W2008143970 @default.
- W2993208081 hasRelatedWork W2156918630 @default.
- W2993208081 hasRelatedWork W2375964497 @default.
- W2993208081 hasRelatedWork W2602420469 @default.
- W2993208081 hasRelatedWork W2888596225 @default.
- W2993208081 hasRelatedWork W2898930391 @default.
- W2993208081 hasRelatedWork W3204961198 @default.
- W2993208081 hasRelatedWork W2185436617 @default.
- W2993208081 hasRelatedWork W2188919139 @default.
- W2993208081 hasVolume "43" @default.
- W2993208081 isParatext "false" @default.
- W2993208081 isRetracted "false" @default.
- W2993208081 magId "2993208081" @default.
- W2993208081 workType "article" @default.