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- W2993218495 abstract "Introduction: Lung cancer is the leading cause of cancer-related deaths, with non-small cell lung cancer (NSCLC) accounting for approximately 85% of all lung cancer cases. The continued advancement of DNA sequencing technology and the discovery of multiple specific driver mutations underlying many cases of NSCLC are moving clinical intervention toward a more targeted approach. Here we focus on anaplastic lymphoma kinase (ALK), a member of the receptor tyrosine kinase family, as an oncogenic driver in NSCLC. The ALK gene is rearranged in 3-7% of NSCLCs, and targeted inhibition of ALK is a viable therapy option.Areas covered: We discuss the available treatment options for ALK-positive NSCLC with an emphasis on the second-generation ALK inhibitor ceritinib. We also discuss practical treatment strategies and possible strategies to overcome or delay resistance to ALK inhibitors.Expert opinion: With a robust treatment armamentarium for patients with ALK-positive NSCLC, emphasis has shifted to optimizing individualized treatment strategies to further enhance outcomes for these patients." @default.
- W2993218495 created "2019-12-13" @default.
- W2993218495 creator A5010032300 @default.
- W2993218495 creator A5082506495 @default.
- W2993218495 date "2019-12-02" @default.
- W2993218495 modified "2023-09-26" @default.
- W2993218495 title "Interpretation of ceritinib clinical trial results and future combination therapy strategies for ALK-rearranged NSCLC" @default.
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- W2993218495 doi "https://doi.org/10.1080/14737140.2019.1699792" @default.
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