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- W2993254160 abstract "The incompleteness of abortion and the severe side effects of single-dose prostaglandin have been extensively recognized. In December 1988, The Obstetric and Gynecological Hospital of Shanghai Medical University started a clinical investigation of the effectiveness of the combined doses of prostaglandin made in China (15-m-Pgf2alpha) with other drugs for early-stage abortion. 123 pregnant women within 49 days of their last menstruation were assigned to 4 groups. Group 1 had 23 cases who used Tamoxifen (TMX) alone orally; group 2 had 20 cases who used a suppository containing both TMX and 15-m-PGF2, combined with oral administration of TMX; group 3 had 20 cases who used injection of TMX with 15-m-Pgf2alpha combined with oral administration TMX; and group 4 used injection of Norethindrone (NET) with 15-m-Pgf2alpha combined with oral administration of NET. The most effective abortifacient combination was in group 4 with 95% complete abortions and 3.3% incomplete abortions. Group 3 ranked second, with 85% complete abortions and 15% incomplete abortions. Group 2 had 50% complete abortions, 30% incomplete abortions and 20% failures. Group 1 had 8.7% complete abortions and 91.3% failures. The higher effectiveness of the combination of NET, rather than TMX, with the prostaglandin showed that NET would be a better choice in the combination. Besides, the cost of TMX was over 30 times higher than NET; therefore, NET should be recommended in clinical use for abortions. Further studies are needed to reduce the dose of prostaglandin and to identify the optimum dosage and combination of NET and TMX with prostaglandin in order to improve the effectiveness of the abortifacient and reduce its side effects." @default.
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- W2993254160 date "1992-08-01" @default.
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- W2993254160 title "[Clinical study of early pregnancy termination by administration of DL-15-methyl prostaglandin F2 alpha combined with tamoxifen or norethisterone]." @default.
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