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• W2993278204 abstract "Nanocarriers are employed to deliver photosensitizers for photodynamic therapy (PDT) through the enhanced penetration and retention effect, but disadvantages including the premature leakage and non-selective release of photosensitizers still exist. Herein, we report a 1O2-responsive block copolymer (POEGMA-b-P(MAA-co-VSPpaMA) to enhance PDT via the controllable release of photosensitizers. Once nanoparticles formed by the block copolymer have accumulated in a tumor and have been taken up by cancer cells, pyropheophorbide a (Ppa) could be controllably released by singlet oxygen (1O2) generated by light irradiation, enhancing the photosensitization. This was demonstrated by confocal laser scanning microscopy and in vivo fluorescence imaging. The 1O2-responsiveness of POEGMA-b-P(MAA-co-VSPpaMA) block copolymer enabled the realization of self-amplified photodynamic therapy by the regulation of Ppa release using NIR illumination. This may provide a new insight into the design of precise PDT." @default.
• W2993278204 created "2019-12-13" @default.
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• W2993278204 date "2020-01-30" @default.
• W2993278204 modified "2023-10-18" @default.
• W2993278204 title "Self‐Amplified Photodynamic Therapy through the ¹ O ₂ ‐Mediated Internalization of Photosensitizers from a Ppa‐Bearing Block Copolymer" @default.
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• W2993278204 doi "https://doi.org/10.1002/anie.201914434" @default.
• W2993278204 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7028480" @default.
• W2993278204 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31808983" @default.
• W2993278204 hasPublicationYear "2020" @default.
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