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- W2993377447 abstract "Objective: As the survival rate and duration increases in the treatment of childhood Hodgkin’s Lymphoma, the incidence of side effects resulting from the treatment increases and the late effects of the treatment become increasingly important. The aim of this study was to evaluate the late side effects of chemotherapy and radiotherapy on thyroid functions in patients treated for Hodgkin’s Lymphoma in childhood. Method: Thyroid functions of 40 patients who were treated with diagnosis of Hodgkin’s Lymphoma, between 1994 and 2013, followed up in remission in Istanbul Health Sciences University, Kanuni Sultan Süleyman Training and Research Hospital, Department of Pediatric Hematology and Oncology, were evaluated retrospectively. Results: The mean age of the patients was 14.13±6.081 (range: 4-31) years, and the male / female ratio was 34/6 (85%/15%). The mean follow-up period was 5.54±3.68 years (0.92-13.92). All patients received chemotherapy. Thirty seven patients (92.5%) received radiotherapy to the neck region. The mean radiotherapy dose was 21.4875±4.48726 Gy. Primary disease was localized to head and neck region in 72.5% of our patients. B symptoms were present in 7 patients (17.5%). Hypothyroidism was detected in 12 of 40 patients (30%) and replacement therapy was started in 5 patients (41%) with the diagnosis of clinical hypothyroidism. Eleven (91%) of these patients were male and 1 (9%) was female. Thyroid gland nodules were detected in 5 (12.5%) of our patients. Of 5 patients with thyroid nodules, 3 were male (60%) and 2 were female (40%). Hypothyroidism was 3.10±2.02 years and thyroid nodule was 8.90±7.10 years. Three patients who were selected according to thyroid scintigraphy and thyroid ultrasonography results were referred to thyroid biopsy and no malignancy was detected. Conclusion: Radiation-induced thyroid diseases in pediatric Hodgkin’s Lymphoma patients may develop during the years following treatment, when the disease is in remission. In particular, patients exposed to neck radiotherapy should be closely monitored for the occurrence of thyroid dysfunction." @default.
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- W2993377447 date "2019-01-01" @default.
- W2993377447 modified "2023-10-06" @default.
- W2993377447 title "Evaluation of Thyroid Functions in Patients Treated Pediatric Hodgkin Lymphoma" @default.
- W2993377447 doi "https://doi.org/10.5222/j.child.2019.45822" @default.
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