FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2993380934> ?p ?o ?g. }

• W2993380934 abstract "Abstract The biggest hurdle to targeted cancer therapy is the inevitable emergence of drug resistance. Tumor cells employ different mechanisms to resist the targeting agent. Most commonly in EGFR -mutant non-small cell lung cancer, secondary resistance mutations on the target kinase domain emerge to diminish the binding affinity of first- and second-generation inhibitors. Other alternative resistance mechanisms include activating complementary bypass pathways and phenotypic transformation. Sequential monotherapies promise to temporarily address the problem of acquired drug resistance, but evidently are limited by the tumor cells’ ability to adapt and evolve new resistance mechanisms to persist in the drug environment. Recent studies have nominated a model of drug resistance and tumor progression under targeted therapy as a result of a small subpopulation of cells being able to endure the drug (minimal residual disease cells) and eventually develop further mutations that allow them to regrow and become the dominant population in the therapy-resistant tumor. This subpopulation of cells appears to have developed through a subclonal event, resulting in driver mutations different from the driver mutation that is tumor-initiating in the most common ancestor. As such, an understanding of intratumoral heterogeneity—the driving force behind minimal residual disease—is vital for the identification of resistance drivers that results from branching evolution. Currently available methods allow for a more comprehensive and holistic analysis of tumor heterogeneity in that issues associated with spatial and temporal heterogeneity can now be properly addressed. This review provides some background regarding intratumoral heterogeneity and how it leads to incomplete molecular response to targeted therapies, and proposes the use of single-cell methods, sequential liquid biopsy, and multiregion sequencing to discover the link between intratumoral heterogeneity and early adaptive drug resistance. In summary, minimal residual disease as a result of intratumoral heterogeneity is the earliest form of acquired drug resistance. Emerging technologies such as liquid biopsy and single-cell methods allow for studying targetable drivers of minimal residual disease and contribute to preemptive combinatorial targeting of both drivers of the tumor and its minimal residual disease cells." @default.
• W2993380934 created "2019-12-13" @default.
• W2993380934 creator A5046579482 @default.
• W2993380934 creator A5058710250 @default.
• W2993380934 date "2019-12-01" @default.
• W2993380934 modified "2023-10-18" @default.
• W2993380934 title "Emerging insights of tumor heterogeneity and drug resistance mechanisms in lung cancer targeted therapy" @default.
• W2993380934 cites W1216419228 @default.
• W2993380934 cites W1536902151 @default.
• W2993380934 cites W1546552389 @default.
• W2993380934 cites W1550376883 @default.
• W2993380934 cites W1835915349 @default.
• W2993380934 cites W1903523058 @default.
• W2993380934 cites W1908940658 @default.
• W2993380934 cites W1933451634 @default.
• W2993380934 cites W1946441967 @default.
• W2993380934 cites W1968061903 @default.
• W2993380934 cites W1968657935 @default.
• W2993380934 cites W1970015742 @default.
• W2993380934 cites W1970476748 @default.
• W2993380934 cites W1972851338 @default.
• W2993380934 cites W1974903221 @default.
• W2993380934 cites W1980497534 @default.
• W2993380934 cites W1983774108 @default.
• W2993380934 cites W1985264867 @default.
• W2993380934 cites W1987283660 @default.
• W2993380934 cites W1997117729 @default.
• W2993380934 cites W1998402190 @default.
• W2993380934 cites W1998971866 @default.
• W2993380934 cites W1999025555 @default.
• W2993380934 cites W2003984225 @default.
• W2993380934 cites W2004325962 @default.
• W2993380934 cites W2011642803 @default.
• W2993380934 cites W2013138515 @default.
• W2993380934 cites W2022540958 @default.
• W2993380934 cites W2022670843 @default.
• W2993380934 cites W2023807845 @default.
• W2993380934 cites W2027735722 @default.
• W2993380934 cites W2028593825 @default.
• W2993380934 cites W2033710904 @default.
• W2993380934 cites W2035252444 @default.
• W2993380934 cites W2044246917 @default.
• W2993380934 cites W2050146483 @default.
• W2993380934 cites W2050249255 @default.
• W2993380934 cites W2056311254 @default.
• W2993380934 cites W2061932411 @default.
• W2993380934 cites W2063707658 @default.
• W2993380934 cites W2066516593 @default.
• W2993380934 cites W2074847845 @default.
• W2993380934 cites W2074932188 @default.
• W2993380934 cites W2076178766 @default.
• W2993380934 cites W2077933920 @default.
• W2993380934 cites W2081953771 @default.
• W2993380934 cites W2092437923 @default.
• W2993380934 cites W2095950160 @default.
• W2993380934 cites W2096387850 @default.
• W2993380934 cites W2097560495 @default.
• W2993380934 cites W2098161852 @default.
• W2993380934 cites W2099203056 @default.
• W2993380934 cites W2103557568 @default.
• W2993380934 cites W2103894337 @default.
• W2993380934 cites W2104411649 @default.
• W2993380934 cites W2106391833 @default.
• W2993380934 cites W2111490539 @default.
• W2993380934 cites W2111662961 @default.
• W2993380934 cites W2115549126 @default.
• W2993380934 cites W2119351872 @default.
• W2993380934 cites W2119424308 @default.
• W2993380934 cites W2120942362 @default.
• W2993380934 cites W2123431502 @default.
• W2993380934 cites W2124729820 @default.
• W2993380934 cites W2126709309 @default.
• W2993380934 cites W2130027352 @default.
• W2993380934 cites W2132157071 @default.
• W2993380934 cites W2133149289 @default.
• W2993380934 cites W2134787029 @default.
• W2993380934 cites W2140126391 @default.
• W2993380934 cites W2146037607 @default.
• W2993380934 cites W2146737519 @default.
• W2993380934 cites W2149542744 @default.
• W2993380934 cites W2153011818 @default.
• W2993380934 cites W2154149901 @default.
• W2993380934 cites W2156078931 @default.
• W2993380934 cites W2156523533 @default.
• W2993380934 cites W2159013299 @default.
• W2993380934 cites W2165385913 @default.
• W2993380934 cites W2169691338 @default.
• W2993380934 cites W2181186240 @default.
• W2993380934 cites W2191042712 @default.
• W2993380934 cites W2194998434 @default.
• W2993380934 cites W2205667543 @default.
• W2993380934 cites W2221542588 @default.
• W2993380934 cites W2231363008 @default.
• W2993380934 cites W2239508872 @default.
• W2993380934 cites W2255615493 @default.
• W2993380934 cites W2257346923 @default.
• W2993380934 cites W2258066491 @default.
• W2993380934 cites W2268267848 @default.
• W2993380934 cites W2272802268 @default.
• W2993380934 cites W2274032786 @default.

• next